Pediatr Allergy Immunol:鼻阻塞性疾病损害永久过敏性鼻炎青少年健康生活质量

2017-05-01 AlexYang MedSci原创

之前,研究人员报道了在患有永久过敏性鼻炎(PER)的儿科病人鼻阻塞性疾病(NOD)较高的流行程度,并且PER对医学治疗并没有响应。最近,研究人员就NOD对该群体生活质量(QoL)的影响进行了研究。研究人员设计的现实生活预期研究包括了142名病人(6-11岁儿童41名,12-17岁青少年101名),这些病人患有中等或者严重的PER。在两个月的医学治疗后(鼻内类固醇和抗组胺),研究人员询问了他们的症状

之前,研究人员报道了在患有永久过敏性鼻炎(PER)的儿科病人鼻阻塞性疾病(NOD)较高的流行程度,并且PER对医学治疗并没有响应。最近,研究人员就NOD对该群体生活质量(QoL)的影响进行了研究。

研究人员设计的现实生活预期研究包括了142名病人(6-11岁儿童41名,12-17岁青少年101名),这些病人患有中等或者严重的PER。在两个月的医学治疗后(鼻内类固醇和抗组胺),研究人员询问了他们的症状是否有改善(是/否)以及通过R(响应)和NR(不响应)来进行分类。研究人员同时评估了他们的鼻症状(视觉模拟评分,VAS)、NOD(鼻内窥镜检查)和QoL(PRQLQ, AdolQRLQ))。

研究结果发现,69名青少年和24名被分到NR组,并且在青少年和儿童中,NR表现较差的QoL总得分,分别为青少年(3.16±1.1 vs. 1.63±0.99; p=0.00001),儿童(2.19±0.82 vs. 1.51±0.77, p=0.02)。在QoL中,医学治疗失败与较差的结果相关(adolescents OR: 1.6, p<0.0001; children OR: 1.04, p=0.036)。另外,研究发现,女性青少年和男性青少年比较表现除了更差的QoL的得分(3.19 vs. 2.36, p=0.001)。在青少年中,阻塞性间隔偏曲(OR: 1.02, p=0.005)、阻塞性鼻甲肥大(OR: 1.03, p=0.0006)以及两种病症的共存(OR=2.06, p=0.001)都与更差的QoL得分相关。研究的发现表明了鼻综合征VAS与QoL有着强烈和高度显著的相关性。最后,研究人员指出,NOD的表现,尤其是在青少年中,与较差的QoL结果相关。因此,NOD在耳科PER中的评估应该在确定治疗方案时加以考虑,并且还要考虑其对病人QoL的影响。

原始出处:

Valls-Mateus M, Marino-Sanchez F, Ruiz-Echevarría K et al. Nasal obstructive disorders impair health-related quality of life in adolescents with persistent allergic rhinitis: a real-life study. Pediatr Allergy Immunol. 19 April 2017. doi: 10.1111/pai.12724.

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    2017-07-10 feather89
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    2018-01-23 tomyang96
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2046829, encodeId=b58a2046829a4, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sun Dec 03 19:02:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726381, encodeId=6aa61e2638108, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Jul 10 05:02:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696711, encodeId=5fd01696e11b1, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Tue Jan 23 06:02:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1966931, encodeId=1f79196693136, content=<a href='/topic/show?id=830e1035383e' target=_blank style='color:#2F92EE;'>#鼻阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103538, encryptionId=830e1035383e, topicName=鼻阻塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Sat Jul 22 21:02:00 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637713, encodeId=0809163e713a4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue May 23 04:02:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1660896, encodeId=59a116608963a, content=<a href='/topic/show?id=a38b2e8752d' target=_blank style='color:#2F92EE;'>#健康生活#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27875, encryptionId=a38b2e8752d, topicName=健康生活)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48dd25178476, createdName=xiaoyang_ambs, createdTime=Fri May 05 03:02:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328938, encodeId=6bb213289389a, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed May 03 10:02:00 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2046829, encodeId=b58a2046829a4, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sun Dec 03 19:02:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726381, encodeId=6aa61e2638108, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Jul 10 05:02:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696711, encodeId=5fd01696e11b1, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Tue Jan 23 06:02:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1966931, encodeId=1f79196693136, content=<a href='/topic/show?id=830e1035383e' target=_blank style='color:#2F92EE;'>#鼻阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103538, encryptionId=830e1035383e, topicName=鼻阻塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Sat Jul 22 21:02:00 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637713, encodeId=0809163e713a4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue May 23 04:02:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1660896, encodeId=59a116608963a, content=<a href='/topic/show?id=a38b2e8752d' target=_blank style='color:#2F92EE;'>#健康生活#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27875, encryptionId=a38b2e8752d, topicName=健康生活)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48dd25178476, createdName=xiaoyang_ambs, createdTime=Fri May 05 03:02:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328938, encodeId=6bb213289389a, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed May 03 10:02:00 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-03 膀胱癌