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Sci Rep：脂多糖引起的永久性鼻炎可引起嗅球胶质增生和突出丧失

2017-09-28 AlexYang MedSci原创

鼻炎脂多糖嗅球
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因嗅黏膜（OM）暴露在环境物质中，因此很容易遭受炎症侵袭。最近，有研究人员为了调查环境毒物引起的OM炎症对嗅球的影响，在小鼠中诱导了永久性的鼻炎，并且分析了在OM和OB中组织病理变化的空间和时间模式。研究人员将小鼠接受单侧鼻内脂多糖（LPS）注射或者生理盐水注射，每周3次，并且在首次注射后的第1、3、7、14和第21天进行免疫组化分析。研究发现，LPS注射诱导了OM的炎症反应，包括了 Ly-6G-

因嗅黏膜（OM）暴露在环境物质中，因此很容易遭受炎症侵袭。最近，有研究人员为了调查环境毒物引起的OM炎症对嗅球的影响，在小鼠中诱导了永久性的鼻炎，并且分析了在OM和OB中组织病理变化的空间和时间模式。

研究人员将小鼠接受单侧鼻内脂多糖（LPS）注射或者生理盐水注射，每周3次，并且在首次注射后的第1、3、7、14和第21天进行免疫组化分析。研究发现，LPS注射诱导了OM的炎症反应，包括了 Ly-6G-、 CD11b-、Iba-1-和CD3-阳性细胞的渗透， CD11b- 和Iba-1-阳性细胞的白介素-1β的产生和嗅觉感应神经元（OSNs）丧失。另外，在OB中，研究人员观察到了小胶质细胞和星形胶质细胞的激活和酪氨酸羟化酶在球周细胞中、囊泡膜谷氨酸转运子1、在冠状和簇状投射神经元中的一个突触前蛋白以及在颗粒细胞中5T4表达的减少。最后，研究人员指出，OM炎症表现出了不利的影响，不仅对OSNs，同时对OB神经元也有不利影响，并且也许会导致神经元退变。

原始出处：

Hasegawa-Ishii S， Shimada A， Imamura F et al. Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb. Sci Rep. 14 September 2017.

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    2017-09-30 方舒

    学习

    0

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    2017-09-30 小刀医生

    #脂多糖#

    0

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    2017-09-29 xuexin53

    学习

    0

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    2017-09-28 天涯183

    非常好的文章.学习了

    0

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    2017-09-28 楠博One

    不可忽视的鼻炎

    0

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季节性过敏性鼻炎（SAR）作为间歇性暴露于季节性花粉中的结果，可以引起鼻子发痒、鼻塞和重复性打喷嚏，并且对生活的品质、工作效率和学校表现具有深远的影响。虽然基因型和环境因素都可能是过敏反应的免疫基础，过敏性鼻炎行管的分子病理阐释仍旧不完全清楚。为了回答这些问题，最近，有研究人员收集了花粉季节时和花粉季节后，来自29名SAR病人和31名对照的鼻上皮刷样本。研究人员进行了基于轨道阱的，倒置免标签定量蛋

Pediatr Allergy Immu：青少年中，屋尘螨舌下免疫治疗药片的合用疗效和安全数据

屋尘螨（HDM）呼吸道过敏在儿童和青少年中是一种常见的和让人烦累的疾病。在患有永久性过敏鼻炎的儿童中，HDM过敏原免疫疗法方法还很少。最近，研究人员进行的后分析利用合用数据来评估青少年中（12-17岁）SQ HDM舌下免疫治疗（SLIT）药片的疗效和安全性。2个双盲、安慰剂对照试验分别在北美和日本进行，研究的主体患有HDM过敏性鼻炎，年龄在12岁以上，并随机进行了一年的治疗。在两个试验中主要的评估