Clin Nutr:帕金森病患者的饮食习惯与神经功能

2016-08-07 Mechront 译 MedSci原创

目的:从适当的营养保健尤其是饮食方面,帕金森氏病患者可以受益很大。然而,关于饮食习惯对帕金森氏症患者疾病功能影响的证据有限。方法:我们进行了一项大的病例对照研究。PD患者(n = 600)接受了系统的营养保健,根据年龄、性别、教育、运动情况和66项食物频率问卷调查结果匹配了健康对照组(n = 600)。调查患者的饮食习惯和PD患者以下特征的联系:体重、能量平衡、便秘、左旋多巴治疗(剂量)和左旋多巴

目的:从适当的营养保健尤其是饮食方面,帕金森氏病患者可以受益很大。然而,关于饮食习惯对帕金森氏症患者疾病功能影响的证据有限。

方法:我们进行了一项大的病例对照研究。PD患者(n = 600)接受了系统的营养保健,根据年龄、性别、教育、运动情况和66项食物频率问卷调查结果匹配了健康对照组(n = 600)。调查患者的饮食习惯和PD患者以下特征的联系:体重、能量平衡、便秘、左旋多巴治疗(剂量)和左旋多巴相关的运动并发症。

结果:相比对照组,帕金森氏症患者有更低的BMI,更高的食物摄入量。BMI与疾病的持续时间、严重程度和左旋多巴相关的运动并发症呈负相关;能量摄入与这些变量呈正相关。在生理需求范围内增加10克蛋白质摄入量(0.8克/公斤/天),左旋多巴剂量对应增加0.7毫克/公斤/天。便秘也与更高左旋多巴需求相关。最后,蛋白质摄入量及其一天中的分布也会影响左旋多巴相关的运动并发症。

结论:蛋白质摄入和便秘治疗的管理应被视为帕金森病患者护理的一个组成部分。注意力应始终集中在能量摄入上,维持营养状态,优化左旋多巴的治疗,最小化左旋多巴相关的运动并发症。

原始出处:


Barichella M.et al.Dietary habits and neurological features of Parkinson's disease patients: Implications for practice.Clin Nutr. 2016 Jul 5. pii: S0261-5614(16)30155-8. doi: 10.1016/j.clnu.2016.06.020

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    2016-10-09 ylzr123

    学习了,文章有深度,值得探究。

    0

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likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:56:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102848, encodeId=b09010284873, content=又是饮食,喝酒会不会?, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Wed Aug 24 10:01:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99454, encodeId=512199454c1, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-09-15 ylzr123

    好文章,赞一个!深入学习,探究。

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-09-09 1e10c84am36(暂无匿称)

    赞!好文章,拜读,深入学习。

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-09-03 李东泽

    很好,不错,以后会多学习

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-24 liusanxin

    又是饮食,喝酒会不会?

    0

  8. 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likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:56:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102848, encodeId=b09010284873, content=又是饮食,喝酒会不会?, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Wed Aug 24 10:01:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99454, encodeId=512199454c1, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-16 忠诚向上

    好好学习一下

    0

  9. 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likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:56:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102848, encodeId=b09010284873, content=又是饮食,喝酒会不会?, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Wed Aug 24 10:01:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99454, encodeId=512199454c1, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-16 huiminghappy

    饮食习惯很重要!

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-09 忠诚向上

    好好学习

    0

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