Pediatrics:看似简单的羊水过多,对后代影响可不简单

2016-01-15 Seven L MedSci原创

研究者对B超提示“羊水过多”的孕妇所分娩的后代进行了短期和长期结局的研究。羊水过多定义为一个正常详细的超声检查中羊水指数(AFI) >24 cm。该研究纳入了134名4-9岁的儿童,其母亲孕期B超检查提示羊水过多,同时按孕产妇年龄、分娩年份、分娩孕周、有无糖尿病等进行匹配,共计268名来自正常羊水孕妈妈的后代。以产后畸形的诊断作为主要结局,产科并发症、遗传综合征和神经发育等作为其他结局指标。

研究者对B超提示“羊水过多”的孕妇所分娩的后代进行了短期和长期结局的研究。羊水过多定义为一个正常详细的超声检查中羊水指数(AFI) >24 cm。

该研究纳入了134名4-9岁的儿童,其母亲孕期B超检查提示羊水过多,同时按孕产妇年龄、分娩年份、分娩孕周、有无糖尿病等进行匹配,共计268名来自正常羊水孕妈妈的后代。以产后畸形的诊断作为主要结局,产科并发症、遗传综合征和神经发育等作为其他结局指标。

研究数据显示,羊水过多会增加剖宫产风险,胎儿出生体重>第90百分位的风险也会增加。剖宫产的增加主要是胎儿可疑巨大儿导致的选择性剖宫产的增加。此外羊水过多还会增加先天畸形风险,羊水过多组和羊水正常组比较,数据分别为25(19%)和27(10%),P= .016;主要畸形发生情况在两组间差异无统计学意义 (11 [8%] vs. 10 [4%]; P = .057)。羊水过多组遗传综合征发生率也更高(5 [3.7%] vs. 2 [0.75%]; P = .043),神经系统疾患和神经发育延迟的情况也更多(9.7% vs. 3%; P = .004)。

研究结果表明,正常详细的孕期超声检查提示羊水过多会导致胎儿畸形、遗传综合症、神经系统疾患、发育延迟等风险增加,并且以上风险的显性极有可能在出生后才能诊断。

原始出处:

Yefet E, Daniel-Spiegel E,et al.Outcomes From Polyhydramnios With Normal Ultrasound.Pediatrics. 2016 Jan 11. pii: peds.2015-1948. [Epub ahead of print]

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    2016-02-03 陈吴1243
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    2016-03-08 hbwxf
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    2016-03-26 feather89
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