健康|中青年人心血管死亡风险增高,竟是它惹的祸!

2018-09-25 牛艳红 医师报

美国学者研究发现,对于身体健康且心血管风险较低的中青年人,如果其低密度脂蛋白胆固醇(LDL-C)水平高于正常范围,则心血管死亡风险将会增加30%~90%,冠心病死亡风险更有可能翻倍。(Circulation. 8月20日在线版)


27年随访:中青年人LDL-C过高
血管死亡风险增30%~90%

美国学者研究发现,对于身体健康且血管风险较低的中青年人,如果其低密度脂蛋白胆固醇(LDL-C)水平高于正常范围,则心血管死亡风险将会增加30%~90%,冠心病死亡风险更有可能翻倍。(Circulation. 8月20日在线版)

研究纳入36 375例受试者,年龄为36~48岁,均无糖尿病和心血管病史,且10年动脉粥样硬化性心血管病(ASCVD)风险<7.5%。中位随访26.8年期间,共发生1086例心血管病和598例冠心病死亡。

分析发现,与LDL-C<100 mg/dl者相比,100~129 mg/dl、130~159 mg/dl、160~189 mg/dl和≥190 mg/dl组受试者的心血管死亡风险分别升高40%、30%、90%和70%。

校正混杂因素后,LDL-C为160~189 mg/dl和≥190 mg/dl者心血管死亡风险分别增加70%和50%;冠心病死亡风险则更高,分别增加120%和100%。

此外,多变量校正模型分析发现,与非高密度脂蛋白胆固醇(HDL-C)<130 mg/dL相比,非HDL-C 160~189 mg/dl, 190~219 mg/dl及≥220 mg/dl分别与心血管死亡风险增加30%、80%和50%相关。

由此可见,无论是LDL-C还是非HDL-C,160 mg/dl都是一个明显的“分界值”,超过这个水平,心血管死亡风险则会增加50%~80%。

研究者还对10年ASCVD风险<5%者进行了分析,并得到一致结果。

PURE研究:多摄入全脂奶制品或更有益于降低心血管和卒中风险

PURE研究对来自21个国家的13.6万余名成人平均追踪9年发现,与很少摄入奶制品或仅摄入低脂奶制品者相比,每天摄入≥2份奶制品可降低心血管病和死亡风险,卒中风险也更低。(Lancet. 9月11日在线版)

一份奶制品是指一杯牛奶(244 g)、一杯酸奶(244 g)、一片奶酪(15 g)或一茶匙黄油(5 g)。

与不摄入奶制品相比,摄入≥2份奶制品(平均3.2份)可降低主要复合终点(心血管死亡、非致死性心梗、卒中或心衰)风险16%,并可降低全因死亡、非心血管死亡、心血管死亡、主要心血管病和卒中风险17%、14%、23%、22%和34%;不过心梗和心衰风险未显著降低。

与不摄入相比,每天摄入1份以上牛奶和酸奶就可降低主要复合终点事件风险,但奶酪和黄油摄入未显著降低该风险。

与每天摄入不到半份奶制品者相比,每天摄入≥2份者的主要复合终点、全因死亡和主要心血管病风险也降低,但只在摄入全脂奶制品时观察到这一关联。

同期述评称,在有更多证据证明全脂奶制品获益更大前,临床医生还是应该仅鼓励患者多摄入低脂奶制品并坚持当前指南。而且,该研究仅分析了基线时的奶制品摄入量,并未考虑印度、中国等国家和地区随着经济增长而发生的生活方式改变;也未考虑更多摄入奶制品者可能更加有健康意识或社会经济条件更好的因素,因此具有一定的局限性。

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    2018-12-08 zll0625
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    2018-09-27 liuxiaona
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    2018-09-27 liuxiaona
  6. [GetPortalCommentsPageByObjectIdResponse(id=1916806, encodeId=664a1916806dc, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Sat Dec 08 16:01:00 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255801, encodeId=85061255801c2, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Sep 27 07:01:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554196, encodeId=59701554196af, content=<a href='/topic/show?id=ab025182080' target=_blank style='color:#2F92EE;'>#心血管死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51820, encryptionId=ab025182080, topicName=心血管死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fb814514579, createdName=huperzia, createdTime=Thu Sep 27 07:01:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561612, encodeId=e06e1561612ff, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Sep 27 07:01:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567621, encodeId=aa26156e6215a, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Sep 27 07:01:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596177, encodeId=abfa15961e73f, content=<a href='/topic/show?id=6e342260237' target=_blank style='color:#2F92EE;'>#中青年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22602, encryptionId=6e342260237, topicName=中青年)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72b18339957, createdName=xuyu, createdTime=Thu Sep 27 07:01:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629870, encodeId=7ca416298e031, content=<a href='/topic/show?id=a913518225e' target=_blank style='color:#2F92EE;'>#心血管死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51822, encryptionId=a913518225e, topicName=心血管死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e76421361831, createdName=baoya, createdTime=Thu Sep 27 07:01:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346593, encodeId=74af346593b5, content= 学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Tue Sep 25 18:43:38 CST 2018, time=2018-09-25, status=1, ipAttribution=)]
    2018-09-27 xuyu
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    2018-09-25 衣带渐宽

    学习

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