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Arthritis Rheumatol： 针对D系列消退素受体系统治疗骨关节炎疼痛

2017-05-27 xiangting MedSci原创

骨关节炎疼痛消退素D关节置换
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在2种不同OA动物模型中，D系列消退素旁路的激活具有强大的镇痛作用。

疼痛是骨关节炎（OA）的主要症状。目前可用的镇痛药要么不能充分缓解疼痛要么与严重的副作用相关。这项研究的目的是调查针对消退素受体系统治疗OA疼痛和病理学的潜力。

在关节置换手术时从OA患者的滑膜和内侧胫骨平台样本中定量分析2个消退素受体（ALX和ChemR23）的基因表达。OA关节疼痛的两种模型用于机械研究。量化关节和中枢神经系统的基因表达。定量分析外源性给予D系列消退素前体17（R） - 羟基 - 二十二碳六烯酸（17 [R] -HDoHE）对疼痛行为、关节病理学、脊髓小胶质细胞病变和星形胶质细胞增生症的作用。使用液相色谱串联质谱法测定大鼠中相关脂质的水平，消退素D2，17（R）-HDoHE和花生四烯酸。

人类OA滑膜和内侧胫骨平台组织中的消退素受体和白细胞介素-6（IL-6）表达呈正相关。在大鼠中，ALX的滑膜表达与IL-1β，肿瘤坏死因子和环加氧酶2的表达呈正相关。17（R）-HDoHE治疗在2例OA疼痛模型中反转了建立的疼痛行为（但不是关节病理学）。这与碘化乙锭诱导的OA大鼠模型中血浆中的消退素D2水平显著升高和脊髓中的星形胶质细胞显著减少有关联。

由此可见，在2种不同OA动物模型中，D系列消退素旁路的激活具有强大的镇痛作用。这些数据支持临床相关的OA疼痛模型的主要中枢作用机制。

原始出处：
Junting Huang, James J. Burston, Li Li, et al. Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain. Arthritis Rheumatol. May 2017. 

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    2018-01-23 lisa438

    #骨关节#

    0

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    2017-12-20 ms6390871039024434

    #Arthritis#

    0

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    2017-09-09 zjshifan_98647306

    #骨关节炎疼痛#

    0

  4. 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    2017-10-10 ms5353107019656438

    #关节炎疼痛#

    0

  5. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun May 28 07:02:25 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203326, encodeId=f078203326ea, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 27 22:49:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29 lmm397

    #关节炎#

    0

  6. 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    2017-05-29 zhaojie88

    #ART#

    0

  7. 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    2017-05-29 12498717m72(暂无昵称)

    #系统治疗#

    0

  8. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun May 28 07:02:25 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203326, encodeId=f078203326ea, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 27 22:49:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-28 135****7952平儿

    学习了。。。。。。。。。

    0

  9. 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CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356286, encodeId=452413562863d, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 06:35:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613988, encodeId=9b91161398892, content=<a href='/topic/show?id=da23e693982' target=_blank style='color:#2F92EE;'>#系统治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76939, encryptionId=da23e693982, topicName=系统治疗)], attachment=null, 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun May 28 07:02:25 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203326, encodeId=f078203326ea, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 27 22:49:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-28 执着追梦

    学习，感谢分享

    0

  10. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Dec 20 18:35:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066186, encodeId=deb42066186b0, content=<a href='/topic/show?id=5f1e1016006d' target=_blank style='color:#2F92EE;'>#骨关节炎疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101600, encryptionId=5f1e1016006d, topicName=骨关节炎疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Sat Sep 09 18:35:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923949, encodeId=7ef419239498a, content=<a href='/topic/show?id=64073011e18' target=_blank style='color:#2F92EE;'>#关节炎疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30117, encryptionId=64073011e18, topicName=关节炎疼痛)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Tue Oct 10 23:35:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265410, encodeId=754e12654100f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon May 29 06:35:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356286, encodeId=452413562863d, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 06:35:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613988, encodeId=9b91161398892, content=<a href='/topic/show?id=da23e693982' target=_blank style='color:#2F92EE;'>#系统治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76939, encryptionId=da23e693982, topicName=系统治疗)], attachment=null, 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun May 28 07:02:25 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203326, encodeId=f078203326ea, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 27 22:49:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-27 清风拂面

    谢谢分享，学习了

    0

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