PLos One:口腔卫生与心脏健康紧密相关

2015-06-29 佚名 生物谷

患有牙周疾病的患者,往往有心血管疾病。牙周疾病是心脏疾病的一个风险因子,就像吸烟和高血压一样。来自阿尔波特大学的研究人员们的最新研究发现,口腔的清洁是如何影响心脏疾病的发病风险的。此项研究结果于近日发表在PLOS ONE杂志上。许多人们没有意识到口腔健康可以影响到全身的器官。此项研究结果表明,患有牙周疾病的患者,有较高的风险发生心血管疾病。研究人员利用临床前小鼠模型,发现了一种新的细胞受体,CD3

患有牙周疾病的患者,往往有心血管疾病。牙周疾病是心脏疾病的一个风险因子,就像吸烟和高血压一样。来自阿尔波特大学的研究人员们的最新研究发现,口腔的清洁是如何影响心脏疾病的发病风险的。此项研究结果于近日发表在PLOS ONE杂志上。

许多人们没有意识到口腔健康可以影响到全身的器官。此项研究结果表明,患有牙周疾病的患者,有较高的风险发生心血管疾病。研究人员利用临床前小鼠模型,发现了一种新的细胞受体,CD36/SR-B2,这种受体可以与口腔中的细菌相互作用,从而引起牙周疾病。CD36/SR-B2可以与Toll样受体相互作用(Toll样受体是免疫系统早期的警戒防线),并产生出一种名为IL-1 beta的蛋白。这种蛋白可以引起炎症,最终导致牙周疾病和动脉粥样硬化。这项发现提供了牙周疾病与心血管疾病相互联系的理论基础。

之前的研究已经证明,Toll样受体是涉及到牙周疾病及心血管疾病的相互关系中的。此项研究发现了CD36/SR-B2是一个新的,共同作用的受体,从而促进了炎症及疾病发生。下一步,研究人员们将开展研究,如何靶向这两种受体,从而阻止心脏疾病的发生。

因此,早期诊断和治疗牙周疾病,对于降低和预防炎症和心脏病风险,至关重要。然而,人们常常在牙周病的早期,由于没有影响到日常生活,所以并不重视,直到牙齿出现松动或是异常才去看牙科医生。事实上,常规的牙齿检查及转业的牙齿清洁,对保持口腔卫生及身体健康,都十分关键。因为许多疾病,早期的诊断和治疗比晚期的治疗简单而且便宜得多。


原始出处:

Paul M. Brown, David J. Kennedy, Richard E. Morton, Maria Febbraio.CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model.PLoS ONE, May 4, 2015.DOI: 10.1371/journal.pone.0125126

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=125045, encodeId=296e125045f2, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:51:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690499, encodeId=4fd416904999a, content=<a href='/topic/show?id=376d38292e6' target=_blank style='color:#2F92EE;'>#口腔卫生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38292, encryptionId=376d38292e6, topicName=口腔卫生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7d3229056256, createdName=bshuang, createdTime=Fri Feb 05 02:56:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789691, encodeId=5efd1e896915b, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon Feb 08 01:56:00 CST 2016, time=2016-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515040, encodeId=5d7e151504055, content=<a href='/topic/show?id=3806514304b' target=_blank style='color:#2F92EE;'>#心脏健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51430, encryptionId=3806514304b, topicName=心脏健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0c810711035, createdName=1179102698_36768929, createdTime=Wed Jul 01 03:56:00 CST 2015, time=2015-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30009, encodeId=27f83000902, content=没错, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Tue Jun 30 10:54:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29978, encodeId=8ea8299e819, content=m, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3ff91626049, createdName=1dd7b2bem83(暂无匿称), createdTime=Tue Jun 30 00:51:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29869, encodeId=5ab1298692c, content=口腔卫生还是很重要的 !, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150824/IMG55DADEB16559C6117.jpg, createdBy=1aa21613630, createdName=ioslove, createdTime=Mon Jun 29 16:41:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29837, encodeId=14c22983e85, content=对,挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Mon Jun 29 14:58:00 CST 2015, time=2015-06-29, status=1, ipAttribution=)]
    2015-06-30 stupidox

    没错

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=125045, encodeId=296e125045f2, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:51:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690499, encodeId=4fd416904999a, content=<a href='/topic/show?id=376d38292e6' target=_blank style='color:#2F92EE;'>#口腔卫生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38292, encryptionId=376d38292e6, topicName=口腔卫生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7d3229056256, createdName=bshuang, createdTime=Fri Feb 05 02:56:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789691, encodeId=5efd1e896915b, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon Feb 08 01:56:00 CST 2016, time=2016-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515040, encodeId=5d7e151504055, content=<a href='/topic/show?id=3806514304b' target=_blank style='color:#2F92EE;'>#心脏健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51430, encryptionId=3806514304b, topicName=心脏健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0c810711035, createdName=1179102698_36768929, createdTime=Wed Jul 01 03:56:00 CST 2015, time=2015-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30009, encodeId=27f83000902, content=没错, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Tue Jun 30 10:54:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29978, encodeId=8ea8299e819, content=m, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3ff91626049, createdName=1dd7b2bem83(暂无匿称), createdTime=Tue Jun 30 00:51:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29869, encodeId=5ab1298692c, content=口腔卫生还是很重要的 !, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150824/IMG55DADEB16559C6117.jpg, createdBy=1aa21613630, createdName=ioslove, createdTime=Mon Jun 29 16:41:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29837, encodeId=14c22983e85, content=对,挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Mon Jun 29 14:58:00 CST 2015, time=2015-06-29, status=1, ipAttribution=)]
    2015-06-29 ioslove

    口腔卫生还是很重要的 !

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=125045, encodeId=296e125045f2, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:51:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690499, encodeId=4fd416904999a, content=<a href='/topic/show?id=376d38292e6' target=_blank style='color:#2F92EE;'>#口腔卫生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38292, encryptionId=376d38292e6, topicName=口腔卫生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7d3229056256, createdName=bshuang, createdTime=Fri Feb 05 02:56:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789691, encodeId=5efd1e896915b, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon Feb 08 01:56:00 CST 2016, time=2016-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1515040, encodeId=5d7e151504055, content=<a href='/topic/show?id=3806514304b' target=_blank style='color:#2F92EE;'>#心脏健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51430, encryptionId=3806514304b, topicName=心脏健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0c810711035, createdName=1179102698_36768929, createdTime=Wed Jul 01 03:56:00 CST 2015, time=2015-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30009, encodeId=27f83000902, content=没错, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Tue Jun 30 10:54:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29978, encodeId=8ea8299e819, content=m, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3ff91626049, createdName=1dd7b2bem83(暂无匿称), createdTime=Tue Jun 30 00:51:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29869, encodeId=5ab1298692c, content=口腔卫生还是很重要的 !, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150824/IMG55DADEB16559C6117.jpg, createdBy=1aa21613630, createdName=ioslove, createdTime=Mon Jun 29 16:41:00 CST 2015, time=2015-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29837, encodeId=14c22983e85, content=对,挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Mon Jun 29 14:58:00 CST 2015, time=2015-06-29, status=1, ipAttribution=)]
    2015-06-29 owlhealth

    对,挺好

    0

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