J Cardiothorac Surg:轻度术前肾功能不全对非体外循环冠状动脉搭桥术后住院及长期结局的影响

2020-03-01 不详 网络

接受单独的非体外循环冠状动脉搭桥术(OPCAB)的患者中,术前轻度肾功能不全并不罕见。但是,目前尚无旨在评估轻度术前肾功能不全对单独的OPCAB手术后医院内和随访结果的影响的研究。这项单中心,回顾性倾向评分匹配研究旨在评估轻度术前肾功能不全对首次单独的OPCAB手术后住院和长期预后的影响。在倾向评分匹配后,纳入2007年1月至2011年12月接受首次OPCAB手术的1236例术前估计肾小球滤过率(

接受单独的非体外循环冠状动脉搭桥术(OPCAB)的患者中,术前轻度肾功能不全并不罕见。但是,目前尚无旨在评估轻度术前肾功能不全对单独的OPCAB手术后医院内和随访结果的影响的研究。这项单中心,回顾性倾向评分匹配研究旨在评估轻度术前肾功能不全对首次单独的OPCAB手术后住院和长期预后的影响。

在倾向评分匹配后,纳入2007年1月至2011年12月接受首次OPCAB手术的1236例术前估计肾小球滤过率(eGFR)大于60 ml / min / 1.73 m2的患者,并分为正常组(eGFR ≥90 ml / min / 1.73 m2,n = 618)和轻度组(eGFR为60-89 ml / min / 1.73 m2,n = 618)。对住院和长期结果进行了调查和回顾性分析。

结果显示,倾向得分匹配的2组具有相似的基线和程序特征,除了基线eGFR以外。在相同的住院期间或手术后30天内有35例患者死亡,手术死亡率为2.8%。随访期间有67例患者死亡,长期生存率为94.1%。单因素分析表明,两组倾向得分匹配组的院内结局发生率相似。Kaplan-Meier曲线显示两组之间的院内生存率相似(χ2= 0.728,p = 0.393),而术前肾功能正常的患者相比轻度术前肾功能不全的病人的长期生存率更高(χ2= 4.722, p = 0.030)。使用Cox比例模型后,轻度术前肾功能不全与术前正常肾功能的患者长期死亡的危险比为1.72(95%CI 1.06-2.83,p = 0.032)。

总之,该研究结果表明,与正常的术前肾功能相比,轻度的术前肾功能不全会降低长期生存率,而没有证据表明院内预后较差。

原始出处:

Qiang Ji, LiMin Xia, et al., Impact of mild preoperative renal insufficiency on in-hospital and long-term outcomes after off-pump coronary artery bypass grafting: a retrospective propensity score matching analysis. J Cardiothorac Surg. 2016; 11: 30. doi: 10.1186/s13019-016-0422-2

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    2020-11-19 yyj062
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    2020-04-25 yese
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    2020-03-03 zzc2214