J Periodontal Res:吸烟对牙周治疗后炎症,龈沟液中骨重塑标记物和龈下微生物的影响

2017-07-28 MedSci MedSci原创

牙周通过抑制微生物介导的局部炎性宿主反应维持健康。吸烟可能会影响这一过程。本研究比较了慢性牙周炎患者治疗期和支持性牙周治疗后,重度吸烟者和非吸烟者的骨改建标志物和龈沟液含量。

牙周通过抑制微生物介导的局部炎性宿主反应维持健康。吸烟可能会影响这一过程。本研究比较了慢性牙周炎患者治疗期和支持性牙周治疗后,重度吸烟者和非吸烟者的骨改建标志物和龈沟液含量。

方法:共50例牙周炎患者(25例吸烟者和25例非吸烟者),在治疗前(T0),治疗期(T1)和12个月的支持性牙周治疗(T2)后从最深的牙周袋中收集龈沟液和龈下菌班。测定血清可替宁水平验证吸烟状态。使用多重复合微单层免疫测定法分析27个炎症和两个骨重建标志物的龈沟液水平,使用棋盘DNA-DNA杂交分析龈下菌斑样品。比较吸烟者和非吸烟者的标记量,计算效果。

结果:吸烟者炎症和骨重建标志物的表达在T0和T2时总体效应降低(p <0.001)。特别是在T0时,促炎标志物(p <0.001),趋化因子(p = 0.007)和生长因子(p = 0.003),T1时的骨保护素(p = 0.003),T2时促炎症标志物(p = 0.019)和趋化因子(p = 0.005 )。在T2时,吸烟者白介素-8水平显着升高。非吸烟者中有10种不同的标记对牙周治疗有反应,吸烟者中没有(p <0.05)。吸烟组和亚组的位点标记物呈≥105个红色复合牙周微生物物种的总体阴性关联。

结论:除了白介素-8的上调之外,吸烟者在T0,T1,T2期几种炎症标志物的龈沟液水平降低。仅非吸烟者的炎症适用于牙周治疗。显然,吸烟似乎具有免疫抑制作用,在牙周治疗后,调节局部炎症反应和龈沟液中捕获的骨重塑标记物。

原始出处:

D. F. Bunæs,M. Mustafa,H. G. Mohamed,et al. The effect of smoking on inflammatory and bone remodeling markers in gingival crevicular fluid and subgingival microbiota following periodontal therapy. Journal of periodontal research. 2017 August. doi: 10.1111/jre.12438

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    2018-03-18 feather89
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    2018-01-02 wjywjy
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