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FMISO PET/CT可以用于预测晚期头颈部肿瘤患者预后

2012-12-14 伊文 好医365

头颈部肿瘤放化疗临床参数
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　　为了探究局部晚期头颈部肿瘤患者在接受放化疗前和放化疗过程中低氧影像的预后预测价值，Daniel Zips等设计了一项前瞻性研究，研究结果发表在Radiother Oncol 10月刊上。 　　有25名III/IV期头颈部肿瘤患者被纳入研究，采用[18F]-fluoromisonidazole (FMISO) PET/CT在放化疗过程中的

　　为了探究局部晚期头颈部肿瘤患者在接受放化疗前和放化疗过程中低氧影像的预后预测价值，Daniel Zips等设计了一项前瞻性研究，研究结果发表在Radiother Oncol 10月刊上。

　　有25名III/IV期头颈部肿瘤患者被纳入研究，采用[18F]-fluoromisonidazole (FMISO) PET/CT在放化疗过程中的4个时间点对患者进行评估，四个时间点分别为入组时、8-10Gy、18-20Gy和50-60Gy。FMISO PET/CT影像学参数包括最大肿瘤本底比值(TBRmax)和不同TBR比率时的阈值量。同时研究者也纳入了CT容量和基线时的FDG-PET/CT影像参数。在所有的时间点都探究了所纳入参数的预后预测价值，其评价价值通过局部无进展生存终点(LPFS)体现。采用多变量Cox和Log评价所研究参数是否存在统计学意义。

　　研究者发现FMISO影像学参数与LPFS终点显著相关，这种相关性在1周和2周时间节点时尤为强烈。基线时各项参数的显著性仅体现在单变量分析时。所有的临床参数，以及FDG-或CT划定肿瘤体积与LPFS都不存在显著相关性。

　　本研究为前瞻性、探索性研究，研究结果证实在治疗初期时FMISO-PET/CT影像学表现具有很强的预后预测价值。在治疗过程中1周或2周时的FMISO-PET/CT影像学表现能够辨别患者手是否会受益于改良后的乏氧或剂量增加治疗。研究者正在进行进一步验证研究。

　　原文链接：Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer



    

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    2013-04-07 bnurmamat

    #患者预后#

    0

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    2013-02-27 feather89

    #PE#

    0

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    2012-12-16 chaojitidian

    #PET/CT#

    0

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    2012-12-16 ms7514935887898259

    #PET#

    0

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    2012-12-16 lanyan20020087

    #肿瘤患者#

    0

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    2012-12-16 wshxjq

    #头颈部#

    0

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    2012-12-16 木头人519

    #颈部#

    0

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