J Periodontal Res: 唾液乳酸脱氢酶水平与全身炎症的关系

2018-07-22 MedSci MedSci原创

据报道,唾液乳酸脱氢酶(LDH)是筛选牙周病的有用参数。我们进行了一项横断面研究,以验证唾液LDH作为牙周炎生物标志物的有效性,并通过测量唾液LDH和血清高敏C-反应蛋白(hs-CRP)水平来研究牙周炎严重程度与全身炎症的关系。

据报道,唾液乳酸脱氢酶(LDH)是筛选牙周病的有用参数。我们进行了一项横断面研究,以验证唾液LDH作为牙周炎生物标志物的有效性,并通过测量唾液LDH和血清高敏C-反应蛋白(hs-CRP)水平来研究牙周炎严重程度与全身炎症的关系。

研究招募了30-79岁的644名男性和1171名女性参与2011 - 15年的香椿健康研究。通过全口检查评估牙周状况,包括探诊深度的平均值,探诊深度≥4mm和≥6mm的百分比,以及探诊出血。收集唾液和血清样本以分别测量唾液LDH水平和hs-CRP。使用线性回归计算唾液LDH的四分位数的线性趋势。使用对数转换的连续唾液LDH和超重状态的交叉乘积项检测唾液LDH和超重者(体重指数≥25kg/ m 2)的相互作用。

结果:针对潜在混杂因素调整的协方差分析显示,男性和女性唾液LDH水平与牙周状况指标(P <.01)之间存在密切关联。根据唾液LDH四分位数,性别和年龄校正的hs-CRP平均值分别为0.40,0.45,0.45和0.50 mg / L(趋势P <.01)。虽然在进一步调整体重指数,高血压糖尿病,血脂异常,酒精摄入量,吸烟状况和身体活动后,这种关联减弱。当按超重状态分层时,超重个体的关联仍然显着(P = .03)。在超重个体中,唾液LDH的最高与最低四分位数的hs-CRP水平≥1mg/ L的多变量校正比值比为1.93(95%CI,1.01-3.69),但在非超重个体中不显着。

唾液LDH似乎是社区健康环境中大规模筛查牙周炎的有希望的生物标志物。高唾液LDH水平,特别是超重个体,可能通过测量全身炎症情况以及传统的心血管危险因素,预防血管疾病。

原始出处:

N. Miyoshi, et al. Association of salivary lactate dehydrogenase level with systemic inflammation in a Japanese population. Journal of Periodontal Research. 2018 June. doi: 10.1111/jre.12537

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    2019-02-24 feather89
  2. [GetPortalCommentsPageByObjectIdResponse(id=1727460, encodeId=a4211e2746048, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 24 04:09:00 CST 2019, time=2019-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334433, encodeId=5332334433ba, content=学习并分享 谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/22/dd84abf830c55b1e8f01eb457283ff8a.jpg, createdBy=0c242333289, createdName=水逆退散终极版, createdTime=Fri Jul 27 06:51:11 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516565, encodeId=504515165650f, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6210986148, createdName=12498dd9m14暂无昵称, createdTime=Tue Jul 24 04:09:00 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333615, encodeId=365f3336151c, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jul 23 15:13:41 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333390, encodeId=a47433339098, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jul 22 13:39:39 CST 2018, time=2018-07-22, status=1, ipAttribution=)]
    2018-07-27 水逆退散终极版

    学习并分享 谢谢

    0

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    2018-07-23 大爰

    学习并分享!!

    0

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    2018-07-22 天地飞扬

    了解一下,谢谢分享!

    0

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