J Clin Res Pediatr Endocrinol:肥胖的儿童、青少年的TSH水平更高

2016-07-09 Mechront 译 MedSci原创

近期有研究表明,肥胖的儿童和青少年与超重或正常体重的同类人群相比,可能有更高水平的促甲状腺激素(TSH)。这些差异的出现,可能是因为肥胖人群的甲状腺自身免疫性疾病的发病率较高所致。阿尔梅里亚Torrecárdenas医院的Emilio García-García博士和同事评估了1317名儿童和青少年(平均年龄8.8岁;女性占48.8%;38.4%的处于青春期),以探究不同体重状态下甲状腺功能和自身

近期有研究表明,肥胖的儿童和青少年与超重或正常体重的同类人群相比,可能有更高水平的促甲状腺激素(TSH)。这些差异的出现,可能是因为肥胖人群的甲状腺自身免疫性疾病的发病率较高所致。

阿尔梅里亚Torrecárdenas医院的Emilio García-García博士和同事评估了1317名儿童和青少年(平均年龄8.8岁;女性占48.8%;38.4%的处于青春期),以探究不同体重状态下甲状腺功能和自身免疫状态的关系,以及高甲促素血症与任何心血管危险因素间的关系。

使用化学发光免疫分析法分析血清游离甲状腺素、TSH、抗过氧化物酶抗体和甲状腺球蛋白抗体浓度;使用Benotti方法测定尿液标本中碘含量。任何抗体有一个结果阳性,那么定义为甲状腺自身免疫性疾病

纳入的参与者中过重、肥胖和超重分别占1.2%、9.8%和21.4%。甲状腺自身免疫患病率为3.7%。与超重(2.79 mU/L) 和正常体重(2.73 mU/L)参与者相比,肥胖者的TSH浓度更高(3.12 mU/L; P = .02)。研究者没有发现游离T4、性别、Tanner分期和年龄的组间差异。

与正常体重(2.9%)参与者相比,超重(6.3%)和肥胖者(5.6%;P = .02)的甲状腺自身免疫性疾病的患病率较高。

校正包括体重在内的混杂因素后,研究者没有发现与TSH相关的心血管危险因素。

“在我们的研究人群中,儿童和青少年肥胖组较超重和正常体重的受试者TSH水平略高,但这些差异,尽管有统计学意义,缺几乎没有临床意义,”研究人员写道。“这项研究还表明,超重和肥胖者的甲状腺自身免疫性疾病的患病率较高,与肥胖相关的高甲促素血症可能与自身免疫性疾病有关。”

原始出处:

arcía-García E, et al.Thyroid Function and Thyroid Autoimmunity in Relation to Weight Status and Cardiovascular Risk Factors in Children and Adolescents: A Population-Based Study. J Clin Res Pediatr Endocrinol. 2016;doi:10.4274/jcrpe.2687.

TSH levels elevated in children, adolescents with obesity.Healio.July 8, 2016

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    2016-09-15 zhouqu_8
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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

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GetPortalCommentsPageByObjectIdResponse(id=92495, encodeId=d1f19249580, content=h搞不明白, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Sat Jul 09 23:01:00 CST 2016, time=2016-07-09, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=92495, encodeId=d1f19249580, content=h搞不明白, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Sat Jul 09 23:01:00 CST 2016, time=2016-07-09, status=1, ipAttribution=)]
    2016-09-14 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=92495, encodeId=d1f19249580, content=h搞不明白, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Sat Jul 09 23:01:00 CST 2016, time=2016-07-09, status=1, ipAttribution=)]
    2016-09-13 舒心和人

    看来肥胖是一件很可怕的事情

    0

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encodeId=707b12569ea4, content=看来肥胖是一件很可怕的事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 20:39:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=119564, encodeId=6d8711956494, content=关注,赞!好文待探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 10 17:08:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407791, encodeId=523e140e791da, content=<a href='/topic/show?id=e0731e891b9' target=_blank style='color:#2F92EE;'>#TSH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17891, encryptionId=e0731e891b9, topicName=TSH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Jul 11 13:44:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92548, encodeId=1e68925482c, content=学习了,青春期冲动, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sun Jul 10 09:55:00 CST 2016, time=2016-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92495, encodeId=d1f19249580, content=h搞不明白, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Sat Jul 09 23:01:00 CST 2016, time=2016-07-09, status=1, ipAttribution=)]
    2016-09-10 ylzr123

    关注,赞!好文待探究。

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=92495, encodeId=d1f19249580, content=h搞不明白, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Sat Jul 09 23:01:00 CST 2016, time=2016-07-09, status=1, ipAttribution=)]
    2016-07-11 xinxin088
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    2016-07-10 明崖

    学习了,青春期冲动

    0

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    2016-07-09 乐奕11

    h搞不明白

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