Lancet Diabetes Endo:生活方式干预对糖耐量异常人群的长期作用研究

2019-04-27 MedSci MedSci原创

研究认为,糖耐量异常人群接受生活方式干预可推迟II型糖尿病的发病,降低并发症风险,这些发现为继续实施和扩大此类干预措施提供了强有力的证据

生活方式干预可以延缓糖耐量异常人群的II型糖尿病风险,但这其对并发症或寿命的影响尚不清楚。本研究旨在评估生活方式干预对糖耐量异常患者糖尿病发病率、并发症和死亡率的长期影响。

研究于1986年在中国大庆33个医疗中心开展, 577名糖耐量异常的成年人接受为期6年的干预措施(饮食、运动或饮食加运动)或对照,随访30年以评估干预对糖尿病发病率、血管疾病事件、复合微血管并发症、心血管疾病死亡、全因死亡率和预期寿命的影响。

在577名参与者中,438名被分配到干预组,138名被分配到对照组,576名受试者中有540名(94%)接受了结果评估(对照组135名,干预组405名)。在30年的随访中,与对照组相比,联合干预组糖尿病发病的平均延迟时间为3.96年,心血管疾病事件(HR:0.74)、微血管并发症发生率(0.65)、心血管疾病死亡人数(0.67)、全因死亡风险(0.74)显著降低,预期寿命平均增长1.44岁。

研究认为,糖耐量异常人群接受生活方式干预可推迟II型糖尿病的发病,降低并发症风险,这些发现为继续实施和扩大此类干预措施提供了强有力的证据。

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    2019-06-25 hb2008ye
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    2019-06-10 howi
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    2019-04-29 fengxx

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