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Diabetologia：糖尿病对结直肠癌分期和死亡风险的影响:基于人群的队列研究

2020-07-20 MedSci原创 MedSci原创

糖尿病；结直肠癌；分期
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糖尿病与结肠直肠癌(CRC)的发病率增加有关。然而，关于糖尿病对癌症特异性死亡率(也称为癌症特异性死亡率)的影响，目前尚存在异议。

糖尿病与结肠直肠癌(CRC)的发病率增加有关。然而，关于糖尿病对癌症特异性死亡率(也称为癌症特异性死亡率)的影响，目前尚存在异议。本研究的目的是确定糖尿病是否与CRC晚期诊断阶段和更高的全因和癌症特异性死亡率有关。

这项回顾性队列研究使用了来自加拿大安大略省的以人口为基础的健康数据库。我们在2007年至2015年诊断为CRC的患者中，比较了糖尿病患者和非糖尿病患者之间出现晚期(III期或IV期)和早期(I期或II期)CRC的可能性，并根据相关协变量进行了校正。然后，我们在校正了CRC诊断阶段和其他协变量后，确定了糖尿病与所有原因和CRC特异性死亡率之间的关系。

研究显示，在44178例CRC患者中，有11822例(26.7%)患有糖尿病。在对CRC筛查和其他协变量进行校正后，糖尿病患者不太可能出现晚期CRC(调整后为OR 0.97, 95% CI 0.93, 1.01)。在2.63(四分位区间[IQR] 0.97-5.10)年的中位随访中，糖尿病与较高的全因死亡率(调整HR 1.08, 95% CI 1.04, 1.12)相关，但与癌症特异性生存率相似(调整HR 1.0, 95% CI 0.95, 1.06)。

研究结果表明，与非糖尿病患者相比，患有CRC的糖尿病患者不太可能出现晚期CRC，癌症特异性死亡率也不高。糖尿病与CRC患者更高的全因死亡率相关，提示有糖尿病的CRC幸存者需要更多的非癌症护理。

原始出处：

Judy K. Qiang，Rinku Sutradhar，Impact of diabetes on colorectal cancer stage and mortality risk: a population-based cohort study

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    2020-10-08 ms5439512287675881

    #BET#

    0

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    2020-09-10 ms9608593228839890

    #DIA#

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    2020-07-22 quxin068

    #死亡风险#

    0

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    2020-07-22 crystal0564

    #结直肠#

    0

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    2020-07-20 lovetcm

    #糖尿病#对各种肿瘤都有影响

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1761457, encodeId=d6311e614574b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Oct 08 18:11:20 CST 2020, time=2020-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639533, encodeId=40c6163953372, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Sep 10 03:11:20 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256008, encodeId=f144125600875, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Jul 22 05:11:20 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453404, encodeId=3c53145340446, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Wed Jul 22 05:11:20 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803565, encodeId=a10080356540, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>对各种肿瘤都有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jul 20 20:56:59 CST 2020, time=2020-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043229, encodeId=92f510432299c, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Jul 20 17:11:20 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2020-07-20 misszhang

    谢谢MedSci提供最新的资讯

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