J Periodontol: 家族性地中海热和慢性牙周炎患者唾液氧化应激的评价

2018-05-28 MedSci MedSci原创

家族性地中海热(FMF)是一种固有的自身炎症性疾病,在地中海国家有很高的发病率。本研究的目的是评估FMF和慢性牙周炎患者唾液中氧化应激参数水平。

家族性地中海热(FMF)是一种固有的自身炎症性疾病,在地中海国家有很高的发病率。本研究的目的是评估FMF和慢性牙周炎患者唾液中氧化应激参数水平。

研究人群由81位FMF患者和85位系统健康对照组成。实验组和对照组分为慢性牙周炎和牙周健康[FMF-牙周炎(n = 37); FMF-牙周健康(n = 44);全身健康-牙周炎(n = 37); 全身和牙周健康(n=48]。收集唾液样本。测定牙周牙菌斑指数(TAS),牙龈指数(GI),探诊深度(PPD),探诊出血百分比(BOP%)和临床附着水平(CAL)。评价唾液总抗氧化状态(TAS),总氧化状态(TOS),8-羟基脱氧鸟苷(8-OHdG),丙二醛(MDA)和氧化应激指数(OSI)。

结果:FMF-牙周炎组的8-OHdG,MDA和OSI水平显着高于FMF-牙周健康组。在FMF-牙周炎组中,PPD,8-OHdG,MDA和OSI水平显着高于全身健康-牙周炎组(P = 0.035,P = 0.000,P = 0.000和P = 0.000)。 8-OHdG值与BOP%和GI显着相关,TOS值与FMF牙周炎组PPD和CAL显着相关。

在FMF和慢性牙周炎的存在下,唾液中的氧化应激水平增加。因此,氧化应激可能是FMF和慢性牙周炎的重要炎症机制。需要进一步的研究阐明FMF和慢性牙周炎的氧化机制。

原始出处:

Din? G, et al. The evaluation of salivary oxidative stress in patients with familial mediterranean fever and chronic periodontitis. Journal of Periodontology. 2018 May. doi:10.1002/JPER.17-0638

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/vLodSSFTQLpHtfwJicWJibSWH7pbiauxvpCMvQIv0N9Oes8vHkDkCIW2HNDkt7icUq3RCZiaDcHR9Rap17fFySRbiaFg/132, createdBy=9f202500205, createdName=ms3297076796458174, createdTime=Sun Nov 18 10:34:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368664, encodeId=a697136866413, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444377, encodeId=c23c14443e7b3, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445222, encodeId=e94a1445222bb, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79df5138909, createdName=ms1260584454294838, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), 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createdBy=303116130321, createdName=wgx311, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629530, encodeId=d34b1629530ee, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26fc21339997, createdName=wetgdt, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319468, encodeId=b39331946817, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 28 22:57:09 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319465, encodeId=1fc131946515, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon May 28 22:51:00 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-30 huagfeg
  5. [GetPortalCommentsPageByObjectIdResponse(id=1727322, encodeId=63411e2732214, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Mar 31 03:34:00 CST 2019, time=2019-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1924304, encodeId=711d1924304d0, content=<a href='/topic/show?id=ff7f464238f' target=_blank style='color:#2F92EE;'>#家族性地中海热#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46423, encryptionId=ff7f464238f, topicName=家族性地中海热)], attachment=null, authenticateStatus=null, 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createdName=131****2916, createdTime=Mon May 28 22:57:09 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319465, encodeId=1fc131946515, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon May 28 22:51:00 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1727322, encodeId=63411e2732214, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Mar 31 03:34:00 CST 2019, time=2019-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1924304, encodeId=711d1924304d0, content=<a href='/topic/show?id=ff7f464238f' target=_blank style='color:#2F92EE;'>#家族性地中海热#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46423, encryptionId=ff7f464238f, topicName=家族性地中海热)], attachment=null, authenticateStatus=null, 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=1450903, encodeId=b3d4145090315, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575477, encodeId=f0c915e5477cf, content=<a href='/topic/show?id=cd9941326bc' target=_blank style='color:#2F92EE;'>#地中海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41326, encryptionId=cd9941326bc, topicName=地中海)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303116130321, createdName=wgx311, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629530, encodeId=d34b1629530ee, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26fc21339997, createdName=wetgdt, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319468, encodeId=b39331946817, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 28 22:57:09 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319465, encodeId=1fc131946515, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon May 28 22:51:00 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-30 wgx311
  8. [GetPortalCommentsPageByObjectIdResponse(id=1727322, encodeId=63411e2732214, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Mar 31 03:34:00 CST 2019, time=2019-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1924304, encodeId=711d1924304d0, content=<a href='/topic/show?id=ff7f464238f' target=_blank style='color:#2F92EE;'>#家族性地中海热#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46423, encryptionId=ff7f464238f, topicName=家族性地中海热)], attachment=null, authenticateStatus=null, 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style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445222, encodeId=e94a1445222bb, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79df5138909, createdName=ms1260584454294838, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), 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createdBy=303116130321, createdName=wgx311, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629530, encodeId=d34b1629530ee, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26fc21339997, createdName=wetgdt, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319468, encodeId=b39331946817, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 28 22:57:09 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319465, encodeId=1fc131946515, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon May 28 22:51:00 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-30 wetgdt
  9. [GetPortalCommentsPageByObjectIdResponse(id=1727322, encodeId=63411e2732214, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Mar 31 03:34:00 CST 2019, time=2019-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1924304, encodeId=711d1924304d0, content=<a href='/topic/show?id=ff7f464238f' target=_blank style='color:#2F92EE;'>#家族性地中海热#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46423, encryptionId=ff7f464238f, topicName=家族性地中海热)], attachment=null, authenticateStatus=null, 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GetPortalCommentsPageByObjectIdResponse(id=1450903, encodeId=b3d4145090315, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575477, encodeId=f0c915e5477cf, content=<a href='/topic/show?id=cd9941326bc' target=_blank style='color:#2F92EE;'>#地中海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41326, encryptionId=cd9941326bc, topicName=地中海)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303116130321, createdName=wgx311, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629530, encodeId=d34b1629530ee, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26fc21339997, createdName=wetgdt, createdTime=Wed May 30 12:34:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319468, encodeId=b39331946817, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 28 22:57:09 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319465, encodeId=1fc131946515, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon May 28 22:51:00 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-28 131****2916

    不错的文章值得推荐

    0

  10. 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createdName=131****2916, createdTime=Mon May 28 22:57:09 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319465, encodeId=1fc131946515, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon May 28 22:51:00 CST 2018, time=2018-05-28, status=1, ipAttribution=)]
    2018-05-28 天地飞扬

    了解一下.谢谢分享!

    0

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评估绿茶对链脲佐菌素诱导的1型糖尿病(T1D)大鼠长期高血糖期间自发性牙周炎进展过程中血管调节的影响。

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控制较差的糖尿病患者的口腔并发症包括唾液流量减少,念珠菌病和牙周症状。最近的一项荟萃分析得出结论认为,与非糖尿病患者相比,糖尿病患者牙周病的严重程度显着增加。