Diabetic Med:初级保健中空腹血糖受损患者的高甘油三酯血症表型和糖尿病风险

2018-10-23 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于初级保健中空腹血糖受损患者的高甘油三酯血症-腰围表型和糖尿病风险的一项队列研究。研究目的是确定初级保健中空腹血糖受损个体的基线甘油三酯 - 腰围表型与糖尿病发病率之间的前瞻性关联。 在常规随访期间,研究人员从三个初级保健诊所招募了空腹血糖异常的1101名参与者(84.4%的招募个体),监测他们的慢性病情况。基线甘油三酯-腰围表型分

近日,国际杂志 《Diabetic Med》上在线发表一项关于初级保健中空腹血糖受损患者的高甘油三酯血症-腰围表型和糖尿病风险的一项队列研究。研究目的是确定初级保健中空腹血糖受损个体的基线甘油三酯 - 腰围表型与糖尿病发病率之间的前瞻性关联。

在常规随访期间,研究人员从三个初级保健诊所招募了空腹血糖异常的1101名参与者(84.4%的招募个体),监测他们的慢性病情况。基线甘油三酯-腰围表型分为四组:(1)正常腰围和甘油三酯水平(n=252; 2)孤立性中心性肥胖(n = 518; 3)孤立的高甘油三酯水平(n = 80);(4)高甘油三酯水平的中心性肥胖(即高甘油三酯血症-腰围表型)(n= 251)。通过美国糖尿病协会的诊断标准确定随访时糖尿病,即空腹血糖(≥7.0mmol /L)和/2小时75 g口服葡萄糖耐量试验(≥11.1mmol /L)和/HbA 1c47.5 mmol /L;6.5%)。建立多变量Cox比例风险回归以评估不同的甘油三酯-腰围表型对糖尿病发作时间的影响。

研究表明,平均随访6.5个月(平均随访时间SD 4.7个月),高甘油三脂-腰表型(52.2%)与其它三个表型组相比,糖尿病病例的数目显著增高(第1组相比:28.2;2组:34.6;3组:30.0%)。在控制混杂因素后,与仅有正常腰围和甘油三酯水平的组相比,只有高甘油三酯 - 腰围表型显示出患糖尿病的风险增加(风险比1.581,95CI 1.172-2.134; P=0.003)。

在初级保健中空腹血糖异常的个体中,向心性肥胖和高甘油三酯血症与6个月内进展为糖尿病的风险> 50%相关。

原始出处:

V. Y.W. Guo E. Y.T. Yu C. K.H. Wonget al. Hypertriglyceridaemic–waist phenotype and risk of diabetes in people with impaired fasting glucose in primary care: a cohort study

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  5. 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  6. 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  7. 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  8. 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CST 2018, time=2018-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535193, encodeId=8044153519318, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Thu Oct 25 07:49:00 CST 2018, time=2018-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609214, encodeId=77b9160921413, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Oct 25 07:49:00 CST 2018, time=2018-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041937, encodeId=9931104193ed9, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Oct 23 19:49:00 CST 2018, time=2018-10-23, status=1, ipAttribution=)]
    2018-10-25 tastas
  9. 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  10. 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authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Oct 25 07:49:00 CST 2018, time=2018-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041937, encodeId=9931104193ed9, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Oct 23 19:49:00 CST 2018, time=2018-10-23, status=1, ipAttribution=)]
    2018-10-23 misszhang

    谢谢MedSci提供最新的资讯

    0

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