CHEST:减肥对OSA的影响

2017-02-15 MedSci MedSci原创

肥胖和阻塞性睡眠呼吸暂停(OSA)之间的相互作用是复杂的。虽然通常认为肥胖是OSA的主要原因,并且治疗OSA可以减轻体重的进一步增加,但是新的证据表明这两者之间的关系可能并不如此。肥胖解释了OSA关于呼吸暂停低通气指数定义的60%的不均一性,主要是<50岁的患者,在老年人中更少。此外,OSA患者使用持续气道正压通气的长期治疗与体重增加有关。这种体重增加效应可能是由于消除与OSA相关的呼吸功增

肥胖和阻塞性睡眠呼吸暂停(OSA)之间的相互作用是复杂的。


虽然通常认为肥胖是OSA的主要原因,并且治疗OSA可以减轻体重的进一步增加,但是新的证据表明这两者之间的关系可能并不如此。

肥胖解释了OSA关于呼吸暂停低通气指数定义的60%的不均一性,主要是<50岁的患者,在老年人中更少。

此外,OSA患者使用持续气道正压通气的长期治疗与体重增加有关。这种体重增加效应可能是由于消除与OSA相关的呼吸功增加而引起。

通过医学或外科技术减轻体重,通常可以治愈2型糖尿病,同样,这种体重减轻对于少数睡眠呼吸暂停的患者也有益。下颌长度较短可以预测更好的结果。

然而,伴随体重减轻的整体呼吸暂停低通气指数的轻微下降可能与非仰卧呼吸暂停低通气指数的较大下降相关,因此将一些患者从非体位性OSA转换为体位性OSA(即仅仰卧)。

重要的是,经历手术减肥的患者需要密切监测以预防并发症。

最后,在患有中度至重度肥胖相关OSA的患者中,CPAP联合减轻体重似乎比单独的任一治疗更有益。

原始出处:
Joosten SA, Hamilton GS, Naughton MT. Impact of Weight Loss Management in OSA. Chest. 2017 Feb 6. pii: S0012-3692(17)30157-5. doi: 10.1016/j.chest.2017.01.027.

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    2017-04-24 Smile2680
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    2017-02-18 1e10c84am36(暂无匿称)

    文章真心不错耶

    0

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    2017-02-17 bioon3

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