J Dent Res：树突状细胞特异性跨膜蛋白作为牙周病骨吸收中破骨细胞的融合剂

2017-03-22 MedSci MedSci原创

树突状细胞特异性跨膜蛋白（DC-STAMP）在诱导破骨细胞融合和DC介导的免疫反应中具有重要作用。虽然DC-STAMP基因在牙周病中的牙龈组织内表达上调，但其病理生理学作用还未可知。

树突状细胞特异性跨膜蛋白（DC-STAMP）在诱导破骨细胞融合和DC介导的免疫反应中具有重要作用。虽然DC-STAMP基因在牙周病中的牙龈组织内表达上调，但其病理生理学作用还未可知。

为了评估DC-STAMP在牙周病中的作用，在结扎诱导的小鼠牙周病模型（n = 6-7/组）中检测抗DC-STAMP的单克隆抗体。结果显示，巴斯德氏菌（Pp）激活的免疫应答反应活化T细胞，产生NFkB配体的受体活化剂（RANKL），随后通过促进破骨发生，导致牙周骨质吸收。在最初培养受到RNAKL刺激的骨髓细胞中，DC-STAMP表达在成熟的多核破骨细胞和不成熟的单核破骨细胞的细胞表面。抗DC-STAMP单克隆抗体抑制大量而不是少量的多核破骨细胞的形成，说明DC-STAMP参与调控末期细胞融合。抗DC-STAMP单克隆抗体也抑制由RANKL刺激的骨髓细胞而形成的凹坑。结扎上颌第二磨牙诱导DC-STAMP mRNA和蛋白表达，同时也增加酒石酸盐抗性酸性磷酸酶阳性（TRAP+）的破骨细胞数量和牙槽骨吸收。正如研究者所预测，全身用药抗DC-STAMP单克隆抗体下调结扎导致的牙槽骨吸收。更为重要的是，局部注射抗DC-STAMP单克隆抗体也能够降低因结扎导致的牙槽骨吸收和多核TRAP+破骨细胞数量。与未结扎的对照部位相比（既未局部注射抗DC-STAMP单克隆抗体，也未注射对照抗体），结扎显着上调肿瘤坏死因子α、白细胞介素-1β和RANKL在牙龈组织内的表达（P<0.05）。不论体内抗Pp IgG抗体还是体外抗Pp的T细胞反应及RANKL的反应产物均受到抗DC-STAMP单克隆抗体的下调影响。

这篇研究阐明了DC-STAMP在不影响对口腔微生物适当的免疫反应条件下，能够促进局部破骨细胞的融合。如此一来，针对DC-STAMP的治疗牙槽骨吸收的新方案似乎具有很大的可行性。

原始出处：

Wisitrasameewong W， Kajiya M， et al. DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption. J Dent Res. 2017 Feb 1：22034517690490. doi： 10.1177/0022034517690490.

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2017-06-26 楚秀娟

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2018-01-23 jinweidong

#特异性#

28 0
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2017-04-10 wgsun

#细胞特异性#

26 0
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2017-03-23 linagood

#牙周病#

32 0
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2017-03-23 caobinglei8079

#破骨细胞#

28 0
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2017-03-23 liuyong2982

#牙周#

19 0
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2017-03-23 jj000004

#骨细胞#

22 0
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2017-03-23 licz0427

#融合#

20 0
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2017-03-23 徐岩

#骨吸收#

26 0

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