PLoS One:唐氏综合症患儿更易发生牙周病

2016-10-14 MedSci MedSci原创

本研究旨在评估并对比唐氏综合征和非唐氏综合征儿童及青少年其唾液中的牙周致病菌。研究共纳入30名唐氏综合症的儿童和青少年(G-DS),以及30名匹配年龄和性别的非唐氏综合征对照者(G-ND)。临床检查确定牙龈出血指数(GBI)和菌斑指数。收集所有研究对象非刺激性全唾液样本。使用荧光原位杂交(FISH)技术检测唾液中的8种牙周致病菌的存在及密度。统计分析包括卡方检验和Mann-Whitney U检验。

本研究旨在评估并对比唐氏综合征和非唐氏综合征儿童及青少年其唾液中的牙周致病菌。

研究共纳入30名唐氏综合症的儿童和青少年(G-DS),以及30名匹配年龄和性别的非唐氏综合征对照者(G-ND)。临床检查确定牙龈出血指数(GBI)和菌斑指数。收集所有研究对象非刺激性全唾液样本。使用荧光原位杂交(FISH)技术检测唾液中的8种牙周致病菌的存在及密度。统计分析包括卡方检验和Mann-Whitney U检验。

结果,与G-ND组相比,G-DS组探诊出血率更高(P = 0.037),直肠弯曲菌(P = 0.013)、牙龈卟啉单胞菌(P = 0.025),齿垢密螺旋体(P = 0.026)、具核梭杆菌(P = 0.013)、中间普氏菌(P = 0.001)和变黑普氏菌(P = 0.008)的密度较高。此外,G-DS组,3-7岁儿童从橙色复合体中分离出的具核梭杆菌(P = 0.029)、中间普氏菌(P = 0.001)和变黑普氏菌(P = 0.006)的密度明显高于G-ND组。8-12岁儿童组空肠弯曲菌的密度较高。

总而言之,该研究结果表明,唐氏综合症的儿童和青少年更易发生牙周病,唾液中牙周致病菌的数量更多。

原始出处:

Faria Carrada C, Almeida Ribeiro Scalioni F,et al., Salivary Periodontopathic Bacteria in Children and Adolescents with Down Syndrome. PLoS One. 2016 Oct 11;11(10):e0162988. doi: 10.1371/journal.pone.0162988.

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    2016-10-15 Carlos007

    牙周病和很多因素有关

    0

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    2016-10-14 有备才能无患

    心脏畸形,牙周病,还有很多

    0

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