Gastroenterology:低剂量阿司匹林不能降低食管癌或胃癌患者死亡风险

2017-11-22 zhangfan MedSci原创

研究认为低剂量的阿司匹林不能降低食管癌或胃癌患者的死亡风险

临床前研究表明阿司匹林具有抗癌特性而流行病学研究显示阿司匹林可延长癌症患者的生存时间。根据之前的研究结论,近日研究人员开展2项大型队列研究考察阿司匹林应用与食管癌或胃癌患者特异性死亡率之间的关系。

1998-2012年间,英格兰和苏格兰新诊断的食管癌或胃癌患者参与研究,服用低剂量的阿司匹林,随访至2015年9月。研究利用时变Cox回归模型考察患者服用低剂量的阿司匹林后肿瘤特异性死亡风险。

总计4654名食管癌以及3833名胃癌患者参与研究,肿瘤特异性死亡患者分别为3240人和2392人。相比于未接受阿司匹林组的患者,接受阿司匹林治疗的食管癌(英格兰队列48% vs 50%,苏格兰队列49% vs 46%)和胃癌(英格兰队列58% vs 57%,苏格兰队列59% vs 55%)患者1年生存率相近。食管癌(HR 0.98)或胃癌(HR 0.96)患者使用低剂量阿司匹林与癌症特异性死亡率降低无相关性。在食管癌(HR 1.03)或胃癌(HR 1.06)确诊后,长期服用阿司匹林不能降低患者肿瘤特异性死亡风险。

研究认为低剂量的阿司匹林不能降低食管癌或胃癌患者的死亡风险。

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channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Apr 18 17:51:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270483, encodeId=a13e2e048348, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Tue Dec 19 06:35:05 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264824, encodeId=f29726482459, content=很好, beContent=null, objectType=article, 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style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Nov 24 01:51:00 CST 2017, time=2017-11-24, status=1, ipAttribution=)]
    2018-03-08 许安
  5. 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  6. 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  7. 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Mon Nov 27 19:39:08 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264111, encodeId=f86b2641112d, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Nov 25 07:22:48 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437277, encodeId=76e2143e27779, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Nov 24 01:51:00 CST 2017, time=2017-11-24, status=1, ipAttribution=)]
    2017-12-19 情途末路

    学习了.获益匪浅!感谢分享

    0

  8. 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Mon Nov 27 19:39:08 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264111, encodeId=f86b2641112d, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Nov 25 07:22:48 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437277, encodeId=76e2143e27779, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Nov 24 01:51:00 CST 2017, time=2017-11-24, status=1, ipAttribution=)]
    2017-11-27 飘飘爱

    很好

    0

  9. 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Mon Nov 27 19:39:08 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264111, encodeId=f86b2641112d, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Nov 25 07:22:48 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437277, encodeId=76e2143e27779, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Nov 24 01:51:00 CST 2017, time=2017-11-24, status=1, ipAttribution=)]
    2017-11-25 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

  10. 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style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Nov 24 01:51:00 CST 2017, time=2017-11-24, status=1, ipAttribution=)]
    2017-11-24 zhouqu_8

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低毒性和高效率是影响纳米材料辅助药物递送在现实临床应用的关键因素。在这项研究中,研究人员研发了尺寸分布较窄的新型空心碳球(HCSs)。除了证明其易于合成以大规模生产之外,研究人员还在体外证明了HCSs在低pH下具有较高的药物负载能力,较低的细胞毒性和最佳的药物释放特征,与肿瘤微环境中的pH相似。此外,HCSs还显示出优异的免疫相容性,并且可在细胞质中快速分散开来以逃脱溶酶体的清除。更重要的是,HC

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2017年9月26日-30日,备受业内瞩目的“第20届全国临床肿瘤大会暨2017年CSCO学术年会”在厦门隆重开幕。本届年会以“传承创新,携手同行”为主题,并继续秉承CSCO的根本宗旨,开展了多种形式的继续教育和学术交流活动。梅斯医学(MedSci)作为特约媒体参加了此次盛会。(CSCO——中国抗癌协会临床肿瘤学协作专业委员会)在此次大会上,来自北京肿瘤医院的张晓东教授以“食管癌的化疗新思考”分享

晚期食管癌何时放疗?中国学者给出了答案

美国San Diego当地时间9月26日,武汉大学人民医院陈永顺教授再次亮相国际会议,在第59届全美放射肿瘤学年会(59th ASTRO)的消化肿瘤专场,受邀展示了一项食管癌的临床原创性研究。

ANN SURG:食管癌环周切缘对预后无影响

尽管远端或近端切缘浸润与不良预后或更高的复发率有关,但是食管切除术后环周切缘在患者生存和肿瘤复发中所扮演的角色仍存在争议。ANN SURG近期发表了一篇文章,研究未接受过治疗的食管癌患者环周切缘(CRM)对生存及复发的影响。

《第八版内科学》中食管癌的内容被画成漫画后……

“民以食为天”、号称“啥都能吃”的中国,是世界上食管癌的高发国家,也是世界上食管癌高死亡率的国家之一。