SCI REP:麻醉药物对食管癌术后患者总生存率和无复发生存率的影响!

2017-10-25 xing.T MedSci原创

与气体麻醉相比较,在食管癌手术中应用TIVA与较好的术后生存率相关。

由于手术应激反应和手术切除可能会增加术后肿瘤扩散和转移的可能性,选择合适的手术麻醉药可能对肿瘤患者预后来说是很重要的。


近日,Scientific reports 杂志上发表了一篇研究文章,研究人员评估了食管癌手术患者进行全身麻醉时所用麻醉药与患者总生存率和无复发生存率之间的关系。

922例成人患者接受了择期食管癌手术,根据患者在手术过程中所有的麻醉药分为两组:气体麻醉(VA)或丙泊酚静脉麻醉(TIVA)。研究人员进行了倾向性评分和Cox回归分析。

VA组有191例患者,TIVA组有731例患者。在整个队列中,研究人员进行多变量分析调整后,发现VA与较差的总生存率(风险比为1.58;95%可信区间为1.24-2.01;P<0.001)和无复发生存率(风险比为1.42;95%可信区间为1.12-1.79;P=0.003)独立相关。同样,在倾向评分匹配队列中,VA与较差的总生存率(风险比为1.45;95%可信区间为1.11-1.89;P=0.006)和无复发生存率(风险比为1.44;95%可信区间为1.11-1.87;P=0.006)相关。

由此可见,与气体麻醉相比较,在食管癌手术中应用TIVA与较好的术后生存率相关。

原始出处:

In-Jung Jun,et al. Impact of anesthetic agents on overall and recurrence-free survival in patients undergoing esophageal cancer surgery: A retrospective observational study.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-14147-9

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    2017-11-01 天涯183

    非常好的文章.学习了

    0

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    2017-10-27 zhouqu_8
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    2017-10-25 三生有幸9135

    学习一下谢谢分享

    0

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    2017-10-25 有备才能无患

    与气体麻醉相比较.在食管癌手术中应用TIVA与较好的术后生存率相关.

    0

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    2017-10-25 thlabcde

    好资料学习了!

    0

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