Neurosurgery:治疗三叉神经痛:γ刀or手术治疗?

2017-04-10 MedSci MedSci原创

背景:伽玛刀(γ刀)是治疗三叉神经痛(TN)的经典方案。目的:回顾性分析长期研究者医院应用γ刀治疗TN的长期预后。方法:对在1993年到2011年期间,在研究者医院应用γ刀治疗TN的患者进行随访。平均最大剂量为86.5 Gy(范围:80-90 Gy;中位数:90 Gy)。按照Burchiel分类定义临床反应。研究者将I和II类作为完全缓解。研究者使用巴罗神经学研究所面部麻木量表评估毒副作用。平均随

背景:伽玛刀(γ刀)是治疗三叉神经痛(TN)的经典方案。

目的:回顾性分析长期研究者医院应用γ刀治疗TN的长期预后。

方法:对在1993年到2011年期间,在研究者医院应用γ刀治疗TN的患者进行随访。平均最大剂量为86.5 Gy(范围:80-90 Gy;中位数:90 Gy)。按照Burchiel分类定义临床反应。研究者将I和II类作为完全缓解。研究者使用巴罗神经学研究所面部麻木量表评估毒副作用。平均随访时间为66个月(范围:24-171月)。

结果:最后随访的患者中,达到完全缓解的为81%,具有良好的反应性,停止药物者占52%。3年、5年及7年的无药物(I级)无痛苦率分别为85%,( CI:78% - 94%),81%年(CI:72% - 91%),和76%(CI:65%)。3年、5年及7年的完全缓解率(I-II类)分别为91%(CI:86% - 97%),86%(CI:79% - 93%),和82%(CI:72% - 93%)。与曾接受过手术治疗的患者相比,药物难治性TN行γ刀治疗的患者,不良的治疗反应率之间存在显著差异。新发的或恶化的面部麻木的患者占32.5%(30%为II分和2.5%为III分)。没有痛觉缺失的报道。疼痛永久性复发率为12%。

结论:与手术治疗的患者相比,γ刀治疗的患者疼痛缓解率较高,且并发症的发生率较低。尽管随着时间的推移,痛苦缓解率下降。研究者认为,应考虑应用γ刀作为药物难治性TN患者的初始治疗。

原文出处:

Martínez Moreno, Nuria E,et al. Long-Term Outcomes in the Treatment of Classical Trigeminal Neuralgia by Gamma Knife Radiosurgery: A Retrospective Study in Patients With Minimum 2-Year Follow-up. Neurosurgery: December 2016


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    2018-01-09 chg121
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    2017-04-12 lsndxfj
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    2017-04-12 贵阳
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    2017-04-11 baihao215

    有指导价值,学习了

    0

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