Stroke:既往抗血小板治疗与脑出血预后之间的相关性分析!

2017-06-09 xing.T MedSci原创

该研究结果表明在脑出血患者中,既往使用CAPT,而不是SAPT,与较高的住院死亡风险相关。

虽然抗血小板治疗(APT)与脑出血(ICH)的风险相关,但是卒中前APT和结局之间相关性的资料较为有限,特别是在联合APT(CAPT)的患者中。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员假设以前使用抗血小板药物与ICH的死亡率增加有关。

研究人员分析了在2012年10月至2016年3月期间来自于1574个脑卒中医院未口服抗凝治疗的82576例ICH患者的临床资料。患者被归类为ICH住院前未进行APT、单一APT(SAPT)和CAPT。研究人员描述了受试者的基础特征、合并症、医院特征和结果,根据APT进行总体和分层分析。

诊断ICH之前,65.8%的患者没有接受APT,29.5%的患者接受了SAPT,以及4.8%的患者接受了CAPT。APT组患者整体住院死亡率适度增加,相比于未接受APT治疗组(24% vs. 23%;调整后的比值比为1.05;95%可信区间为1.01-1.10)。虽然接受SAPT和CAPT的患者年龄较大,在合并症方面有较高的风险谱。在接受SAPT的患者和未接受任何APT的患者在住院死亡率上无显著差异(23% vs. 23%;调整后的比值比为1.01;95%可信区间为0.97-1.05)。然而,接受CAPT的患者住院死亡率较高,相比于那些未进行APT的患者(30% vs. 23%;调整后的比值比为1.50;95%可信区间为1.39-1.63)。

该研究结果表明在脑出血患者中,既往使用CAPT,而不是SAPT,与较高的住院死亡风险相关。

原始出处:

Nadeem I. Khan, et al. Association Between Previous Use of Antiplatelet Therapy and Intracerebral Hemorrhage Outcomes.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.016290

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    2017-12-15 jefee1214

    学习了.谢谢

    0

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    2017-06-09 thlabcde

    好东西学习了!

    0

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