AP&T: 利福昔明可以降低肝移植等候名单中患者自发性细菌性腹膜炎,静脉曲张出血和全因入院的发生率

2019-08-10 不详 MedSci原创

有研究表明,利福昔明可降低肝性脑病(HE)的风险,并可显着降低住院率和30天再入院率。本项研究旨在验证利福昔明在治疗肝移植的患者的治疗效果。

背景
有研究表明,利福昔明可降低肝性脑病(HE)的风险,并可显着降低住院率和30天再入院率。本项研究旨在验证利福昔明在治疗肝移植的患者的治疗效果。

方法
研究人员回顾性分析了2年内肝移植的患者记录。所有患者均至少有两次明显的HE发作导致住院治疗或者在评估时发生肝性脑病。

结果
在本项研究中共纳入622名患者,其中101名患有HE。六十六名患者接受利福昔明治疗,肝移植等候名单上的患者使用利福昔明治疗后减少了全因入院率,自发性细菌性腹膜炎和静脉曲张出血的发生风险。利福昔明治疗组的平均住院时间为9天(95%CI 6-12),而非利福昔明组中的平均住院时间为14天(95%CI :7-21)。多元回归分析显示,利福昔明与降低再入院平均天数独立相关。

结论
利福昔明可改善肝移植患者的预后,并显着降低与自发性细菌性腹膜炎,腹水和静脉曲张出血相关的入院率。

原始出处:

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    2020-02-01 fusion
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    2019-08-12 sodoo
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    2019-08-12 xuyong530

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