Sci Rep:异氟醚麻醉在阴茎海绵体内压检测中的研究

2017-11-07 AlexYang MedSci原创

阴茎海绵体内压(ICP)是动物阴茎勃起功能检测的黄金标准,但是关于应该应用什么样的麻醉方法还没有达成一致的意见。最近,有研究人员将总共16只成年雄性斯普拉格-杜勒鼠随机分成了2个小组。在组A,研究人员对其进行水合氯醛腹腔内注射给药。而在组B中的小鼠先在5%异氟烷中诱导3分钟,之后维持在1.0-1.5%异氟烷中。研究人员对所有实验的平均动脉压(MAP)、呼吸频率(RR)和心跳速率进行了监测。在ICP

阴茎海绵体内压(ICP)是动物阴茎勃起功能检测的黄金标准,但是关于应该应用什么样的麻醉方法还没有达成一致的意见。

最近,有研究人员将总共16只成年雄性斯普拉格-杜勒鼠随机分成了2个小组。在组A,研究人员对其进行水合氯醛腹腔内注射给药。而在组B中的小鼠先在5%异氟烷中诱导3分钟,之后维持在1.0-1.5%异氟烷中。研究人员对所有实验的平均动脉压(MAP)、呼吸频率(RR)和心跳速率进行了监测。

在ICP检测后,研究人员收集了尾静脉和颈动脉血液。在组B中,最大ICP值、MAP和ICP/MAP比例要比组A显著更高。组A中的RR要比组B中的RR更低,但是心跳速率在组A中要比组B更高。在pO2和pCO2方面,两个小组之间均没有显著的差异。然而,数据表明,组A相对血氧过低。最后,研究人员指出,异氟醚麻醉在阴茎勃起功能中的检测能够提供一种比水合氯醛腹腔麻醉相对更加稳定身体状态。因此,异氟醚麻醉对ICP测试更加适用。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1945735, encodeId=e5211945e359b, content=<a href='/topic/show?id=ce36656504b' target=_blank style='color:#2F92EE;'>#海绵体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65650, encryptionId=ce36656504b, topicName=海绵体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37d0457, createdName=yhj-time, createdTime=Tue Mar 06 22:26:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973971, encodeId=048519e397155, content=<a href='/topic/show?id=827b49808cd' target=_blank style='color:#2F92EE;'>#异氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49808, encryptionId=827b49808cd, topicName=异氟醚)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Sat Dec 23 06:26:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293888, encodeId=b960129388844, content=<a href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Nov 09 12:26:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579017, encodeId=b93615e9017e4, content=<a href='/topic/show?id=1c829e55888' target=_blank style='color:#2F92EE;'>#阴茎海绵体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97558, encryptionId=1c829e55888, topicName=阴茎海绵体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=608816488404, createdName=ms3323097325231039, createdTime=Thu Nov 09 12:26:00 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1945735, encodeId=e5211945e359b, content=<a href='/topic/show?id=ce36656504b' target=_blank style='color:#2F92EE;'>#海绵体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65650, encryptionId=ce36656504b, topicName=海绵体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37d0457, createdName=yhj-time, createdTime=Tue Mar 06 22:26:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973971, encodeId=048519e397155, content=<a href='/topic/show?id=827b49808cd' target=_blank style='color:#2F92EE;'>#异氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49808, encryptionId=827b49808cd, topicName=异氟醚)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Sat Dec 23 06:26:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293888, encodeId=b960129388844, content=<a href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Nov 09 12:26:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579017, encodeId=b93615e9017e4, content=<a href='/topic/show?id=1c829e55888' target=_blank style='color:#2F92EE;'>#阴茎海绵体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97558, encryptionId=1c829e55888, topicName=阴茎海绵体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=608816488404, createdName=ms3323097325231039, createdTime=Thu Nov 09 12:26:00 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1945735, encodeId=e5211945e359b, content=<a href='/topic/show?id=ce36656504b' target=_blank style='color:#2F92EE;'>#海绵体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65650, encryptionId=ce36656504b, topicName=海绵体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37d0457, createdName=yhj-time, createdTime=Tue Mar 06 22:26:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973971, encodeId=048519e397155, content=<a href='/topic/show?id=827b49808cd' target=_blank style='color:#2F92EE;'>#异氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49808, encryptionId=827b49808cd, topicName=异氟醚)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Sat Dec 23 06:26:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293888, encodeId=b960129388844, content=<a href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Nov 09 12:26:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579017, encodeId=b93615e9017e4, content=<a href='/topic/show?id=1c829e55888' target=_blank style='color:#2F92EE;'>#阴茎海绵体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97558, encryptionId=1c829e55888, topicName=阴茎海绵体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=608816488404, createdName=ms3323097325231039, createdTime=Thu Nov 09 12:26:00 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-09 dingxiaobo
  4. [GetPortalCommentsPageByObjectIdResponse(id=1945735, encodeId=e5211945e359b, content=<a href='/topic/show?id=ce36656504b' target=_blank style='color:#2F92EE;'>#海绵体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65650, encryptionId=ce36656504b, topicName=海绵体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37d0457, createdName=yhj-time, createdTime=Tue Mar 06 22:26:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973971, encodeId=048519e397155, content=<a href='/topic/show?id=827b49808cd' target=_blank style='color:#2F92EE;'>#异氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49808, encryptionId=827b49808cd, topicName=异氟醚)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Sat Dec 23 06:26:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293888, encodeId=b960129388844, content=<a href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Nov 09 12:26:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579017, encodeId=b93615e9017e4, content=<a href='/topic/show?id=1c829e55888' target=_blank style='color:#2F92EE;'>#阴茎海绵体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97558, encryptionId=1c829e55888, topicName=阴茎海绵体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=608816488404, createdName=ms3323097325231039, createdTime=Thu Nov 09 12:26:00 CST 2017, time=2017-11-09, status=1, ipAttribution=)]

相关资讯

PLoS One:异氟醚麻醉为何会导致老年人AD相关的认知障碍?

研究已表明异氟醚麻醉是导致老年人阿尔茨海默病(AD)认知障碍和AD发展的主要原因。然而,异氟醚麻醉诱导AD相关认知功能障碍的发病机制目前尚未可知。因此,本研究旨在探讨异氟醚麻醉引起AD相关认知功能障碍的机制。 研究将Wistar大鼠随机分为6组(n = 12),1个对照组(CONT)和5个异氟醚(ISO)治疗组(ISO 0,ISO 0.5d、ISO 1d、ISO 3d、ISO 7d)。对照组