神经科

订阅

MedSci主页 / 所有栏目 / 神经科

Nature：阿尔茨海默氏症的新遗传风险变异体

2014-02-08 Natureasia Natureasia

阿尔茨海默氏症遗传风险变异体Nature
关注

RR淀粉质前体蛋白、presenilin 1和 presenilin 2中引起阿尔茨海默氏症的突变的识别，使我们对这种疾病的病理生物学有了更好的认识。预计还会发现进一步的突变，但识别这种变异体一直具有挑战性。 本文作者采用外显子组测序方法来识别对晚发病的阿尔茨海默氏症有很大影响的低频率编码变异体。他们报告了PLD3基因中的几个编码变异体（编码磷脂酶D3），这些变异体至少将患病风险增加两倍


RR淀粉质前体蛋白、presenilin 1和 presenilin 2中引起阿尔茨海默氏症的突变的识别，使我们对这种疾病的病理生物学有了更好的认识。预计还会发现进一步的突变，但识别这种变异体一直具有挑战性。

本文作者采用外显子组测序方法来识别对晚发病的阿尔茨海默氏症有很大影响的低频率编码变异体。他们报告了PLD3基因中的几个编码变异体（编码磷脂酶D3），这些变异体至少将患病风险增加两倍。

PLD3也许在也也淀粉质的处理中起一定作用，并且还具有作为一个新的治疗目标的潜力。

原文出处：

Cruchaga C1, Karch CM2, Jin SC3, Benitez BA4, Cai Y4, Guerreiro R5, Harari O4, Norton J4, Budde J4, Bertelsen S4, Jeng AT4, Cooper B4, Skorupa T4, Carrell D4, Levitch D4, Hsu S4, Choi J4, Ryten M6; UK Brain Expression Consortium, Hardy J6, Ryten M6, Trabzuni D6, Weale ME7, Ramasamy A7, Smith C8, Sassi C5, Bras J6, Gibbs JR5, Hernandez DG5, Lupton MK9, Powell J10, Forabosco P11, Ridge PG12, Corcoran CD13, Tschanz JT14, Norton MC15, Munger RG16, Schmutz C12, Leary M12, Demirci FY17, Bamne MN17, Wang X17, Lopez OL18, Ganguli M19, Medway C20, Turton J20, Lord J20, Braae A20, Barber I20, Brown K20; Alzheimer’s Research UK Consortium, Passmore P21, Craig D21, Johnston J21, McGuinness B21, Todd S21, Heun R22, Kölsch H23, Kehoe PG24, Hooper NM25, Vardy ER26, Mann DM27, Pickering-Brown S27, Brown K20, Kalsheker N20, Lowe J20, Morgan K20, David Smith A28, Wilcock G28, Warden D28, Holmes C28, Pastor P29, Lorenzo-Betancor O30, Brkanac Z31, Scott E32, Topol E32, Morgan K20, Rogaeva E33, Singleton AB34, Hardy J6, Kamboh MI35, St George-Hyslop P36, Cairns N37, Morris JC38, Kauwe JS12, Goate AM39.Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.Nature. 2014 Jan 23;505(7484):550-4. doi: 10.1038/nature12825. Epub 2013 Dec 11.【原文下载】

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1817628, encodeId=8579181e62859, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jan 08 05:49:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879907, encodeId=a14818e990759, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Dec 17 10:49:00 CST 2014, time=2014-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816605, encodeId=c92618166058c, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 23 23:49:00 CST 2014, time=2014-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951288, encodeId=10cc1951288d8, content=<a href='/topic/show?id=a85338105b8' target=_blank style='color:#2F92EE;'>#变异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38105, encryptionId=a85338105b8, topicName=变异体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Thu Sep 11 04:49:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990365, encodeId=f34b1990365db, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sun Dec 07 23:49:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342292, encodeId=af011342292b8, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361906, encodeId=93dd1361906a9, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469982, encodeId=f61d146998241, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=)]
    2015-01-08 12498da4m32(暂无昵称)

    #阿尔茨海#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1817628, encodeId=8579181e62859, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jan 08 05:49:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879907, encodeId=a14818e990759, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Dec 17 10:49:00 CST 2014, time=2014-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816605, encodeId=c92618166058c, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 23 23:49:00 CST 2014, time=2014-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951288, encodeId=10cc1951288d8, content=<a href='/topic/show?id=a85338105b8' target=_blank style='color:#2F92EE;'>#变异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38105, encryptionId=a85338105b8, topicName=变异体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Thu Sep 11 04:49:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990365, encodeId=f34b1990365db, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sun Dec 07 23:49:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342292, encodeId=af011342292b8, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361906, encodeId=93dd1361906a9, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469982, encodeId=f61d146998241, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=)]
    2014-12-17 liye789132251

    #Nat#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1817628, encodeId=8579181e62859, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jan 08 05:49:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879907, encodeId=a14818e990759, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Dec 17 10:49:00 CST 2014, time=2014-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816605, encodeId=c92618166058c, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 23 23:49:00 CST 2014, time=2014-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951288, encodeId=10cc1951288d8, content=<a href='/topic/show?id=a85338105b8' target=_blank style='color:#2F92EE;'>#变异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38105, encryptionId=a85338105b8, topicName=变异体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Thu Sep 11 04:49:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990365, encodeId=f34b1990365db, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sun Dec 07 23:49:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342292, encodeId=af011342292b8, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361906, encodeId=93dd1361906a9, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469982, encodeId=f61d146998241, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=)]
    2014-07-23 ms1948154235210413

    #阿尔茨#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1817628, encodeId=8579181e62859, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jan 08 05:49:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879907, encodeId=a14818e990759, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Dec 17 10:49:00 CST 2014, time=2014-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816605, encodeId=c92618166058c, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 23 23:49:00 CST 2014, time=2014-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951288, encodeId=10cc1951288d8, content=<a href='/topic/show?id=a85338105b8' target=_blank style='color:#2F92EE;'>#变异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38105, encryptionId=a85338105b8, topicName=变异体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Thu Sep 11 04:49:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990365, encodeId=f34b1990365db, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sun Dec 07 23:49:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342292, encodeId=af011342292b8, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361906, encodeId=93dd1361906a9, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469982, encodeId=f61d146998241, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=)]
    2014-09-11 chenwq08

    #变异体#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1817628, encodeId=8579181e62859, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jan 08 05:49:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879907, encodeId=a14818e990759, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Dec 17 10:49:00 CST 2014, time=2014-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816605, encodeId=c92618166058c, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 23 23:49:00 CST 2014, time=2014-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951288, encodeId=10cc1951288d8, content=<a href='/topic/show?id=a85338105b8' target=_blank style='color:#2F92EE;'>#变异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38105, encryptionId=a85338105b8, topicName=变异体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Thu Sep 11 04:49:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990365, encodeId=f34b1990365db, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sun Dec 07 23:49:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342292, encodeId=af011342292b8, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361906, encodeId=93dd1361906a9, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469982, encodeId=f61d146998241, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=)]
    2014-12-07 zhs3882

    #阿尔茨海默氏#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1817628, encodeId=8579181e62859, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jan 08 05:49:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879907, encodeId=a14818e990759, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Dec 17 10:49:00 CST 2014, time=2014-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816605, encodeId=c92618166058c, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 23 23:49:00 CST 2014, time=2014-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951288, encodeId=10cc1951288d8, content=<a href='/topic/show?id=a85338105b8' target=_blank style='color:#2F92EE;'>#变异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38105, encryptionId=a85338105b8, topicName=变异体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Thu Sep 11 04:49:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990365, encodeId=f34b1990365db, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sun Dec 07 23:49:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342292, encodeId=af011342292b8, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361906, encodeId=93dd1361906a9, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469982, encodeId=f61d146998241, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=)]
    2014-02-10 12498dabm77暂无昵称

    #变异#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1817628, encodeId=8579181e62859, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jan 08 05:49:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879907, encodeId=a14818e990759, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Dec 17 10:49:00 CST 2014, time=2014-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816605, encodeId=c92618166058c, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 23 23:49:00 CST 2014, time=2014-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951288, encodeId=10cc1951288d8, content=<a href='/topic/show?id=a85338105b8' target=_blank style='color:#2F92EE;'>#变异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38105, encryptionId=a85338105b8, topicName=变异体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Thu Sep 11 04:49:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990365, encodeId=f34b1990365db, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sun Dec 07 23:49:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342292, encodeId=af011342292b8, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361906, encodeId=93dd1361906a9, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469982, encodeId=f61d146998241, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=)]
    2014-02-10 docwu2019

    #遗传风险#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1817628, encodeId=8579181e62859, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Thu Jan 08 05:49:00 CST 2015, time=2015-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879907, encodeId=a14818e990759, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Dec 17 10:49:00 CST 2014, time=2014-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816605, encodeId=c92618166058c, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jul 23 23:49:00 CST 2014, time=2014-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951288, encodeId=10cc1951288d8, content=<a href='/topic/show?id=a85338105b8' target=_blank style='color:#2F92EE;'>#变异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38105, encryptionId=a85338105b8, topicName=变异体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Thu Sep 11 04:49:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990365, encodeId=f34b1990365db, content=<a href='/topic/show?id=b8eb9e78216' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97782, encryptionId=b8eb9e78216, topicName=阿尔茨海默氏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b952312, createdName=zhs3882, createdTime=Sun Dec 07 23:49:00 CST 2014, time=2014-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342292, encodeId=af011342292b8, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361906, encodeId=93dd1361906a9, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469982, encodeId=f61d146998241, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=)]
    2014-02-10 yhj-time

    #阿尔茨海默#

    0

相关资讯

JAD：阿尔茨海默氏症研究获进展

阿尔茨海默氏症的并发原因一直是困扰基因组学与遗传学界的科学难题，中国科学院北京基因组研究所研究员雷红星全面分析了国外脑转录组的数据，发现在阿尔茨海默氏症患者的脑部转录组中，第19号染色体区域（chr19p）是最显著扰动的染色体区域，并提出了基因组和转录组两方面的证据，来表明该区域在阿尔茨海默氏症致病机理中起到特殊作用。相关研究成果发表在8月份的《阿尔茨海默氏症》杂志上。【原文下载】 阿尔茨海默氏

J Neuroinflammation：阻断过度活化受体恢复阿尔茨海默氏症小鼠记忆功能

近日，一项新的研究表明，老年小鼠阿尔茨海默氏症的病理记忆可以逆转得到恢复治疗。蒙特利尔神经学研究所、麦吉尔大学和蒙特利尔大学的研究人员的研究发现，阻断阿尔茨海默氏病（AD）小鼠大脑中的一个特定的受体的活性，能恢复记忆和脑功能。 研究结果发表在Journal of Neuroinflammation杂志上，新研究揭示了AD的基本机制，并标明该受体可作为一个潜在的新疗法靶标。 神经学家Edith

Nat Med：一种通路会诱发阿尔茨海默氏症和朊病毒病

《自然—医学》上的一项研究发现了一种对阿尔茨海默氏症（又称老年痴呆症）和朊病毒疾病发展有促进作用的共同通路。抑制该通路可减缓小鼠体内这两类疾病的发病过程，这意味着开发针对该通路的单一药物可能会对治疗这两类疾病有所帮助。 在这两类疾病中，淀粉样前体蛋白和朊蛋白会在细胞表面分别发生分裂。一种名为α-分泌酶分裂的保护性通路会让这些蛋白阻碍在发病过程中积累的有毒蛋白的形成。 Benoit Schnei

Nature：阿尔茨海默氏症病因新解读

由美国麻省大学医学院、波恩大学和德国先进欧洲学习与研究中心的研究人员组成的一个国际研究小组，在新研究中证实一个众所周知的免疫炎症过程在阿尔茨海默氏症的病理学中发挥了重要的作用。这一过程导致生成了成熟的促炎性细胞因子白细胞介素1β（IL-1B），与机体抵御感染相关，因此被确立为类风湿性关节炎的一个临床靶点。这一发表在《自然》（Nature）杂志上的研究发现指出了破坏IL-1B生成的药物，例如类风湿性

Nat Commun ：一种新型多肽C99能遏制阿尔茨海默氏症发病

日本同志社大学的一个研究小组宣布，他们开发出一种新物质，能遏制导致阿尔茨海默氏症（早老性痴呆）的β淀粉样蛋白的生成。这一成果将有助于开发出副作用很小的预防和治疗阿尔茨海默氏症的方法。【原文下载】 同志社大学副教授舟本聪率领的研究小组发现，一种酶与一种称为“C99”的蛋白质结合之后形成β淀粉样蛋白。如果遏制这种酶发挥作用，就有可能对阿尔茨海默氏症进行治疗。但是，由于这种

AAIC 2013:灵北及大冢新药Lu AE58054能显著改善AD认知

灵北制药（Lundbeck）和大冢制药（Otsuka）7月17日在波士顿举行的2013年度阿尔茨海默氏症协会国际会议（AAIC 2013）上公布了实验性药物Lu AE58054的首批临床数据。 该II期临床研究是一项多中心、随机、双盲、平行组、安慰剂对照试验，在欧洲、加拿大、澳大利亚等国278例中度阿尔茨海默氏症（Alzheimer's disease，AD）患者中开展，探索了Lu AE58