BMJ:促排卵后出生的孩子精神障碍风险高

2013-07-17 青楚 BMJ

丹麦学者的一项研究显示,与自然怀孕出生的孩子相比,经过促排卵/宫腔内人工授精后出生的孩子精神障碍发生率略高,经过体外受精/胞浆内单精子注射出生的孩子总体风险更高。相关论文2013年7月5日在线发表于《英国医学杂志》(BMJ)。 该回顾性队列研究纳入1995-2003年期间出生在丹麦的儿童,随访到2012年,儿童为8-17岁时。其中33 139个孩子通过辅助生殖技术出生,其他555 828个孩子自

丹麦学者的一项研究显示,与自然怀孕出生的孩子相比,经过促排卵/宫腔内人工授精后出生的孩子精神障碍发生率略高,经过体外受精/胞浆内单精子注射出生的孩子总体风险更高。相关论文2013年7月5日在线发表于《英国医学杂志》(BMJ)。

该回顾性队列研究纳入1995-2003年期间出生在丹麦的儿童,随访到2012年,儿童为8-17岁时。其中33 139个孩子通过辅助生殖技术出生,其他555 828个孩子自然受孕后出生。 主要观察指标是总体和各种特定精神障碍的绝对危险值和危险比。

结果显示,与自然怀孕出生的孩子相比,经过体外受精/胞浆内单精子注射出生的孩子精神障碍风险并不高,除外抽动障碍显著增加外(危险比为1.40,95% CI为1.01-1.95,绝对危险值0.3%)。相反,经过促排卵(伴有或不伴有宫腔内人工授精)后出生的孩子精神障碍(危险比为1.20,95% CI为1.11-1.31,绝对危险值4.1%)、自闭症谱系障碍(危险比为1.20,95% CI为1.05 to 1.37,绝对危险值1.5%)、多动障碍(危险比为1.23, 95% CI为1.08-1.40; 1.7%)、 行为、情绪或社交障碍(危险比为1.21,95% CI为1.02-1.45,绝对危险值0.8%)和抽动障碍(危险比为1.51,95% CI为1.16-1.96,绝对危险值0.4%)的风险均显著升高。

研究链接:Fertility treatment and risk of childhood and adolescent mental disorders: register based cohort study 

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    2014-04-13 gaoxiaoe
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