GUT:HCV患者实现SVR后肝外疾病风险显著降低

2018-05-02 zhangfan MedSci原创

研究认为,对于HCV感染人群,抗病毒治疗后实现SVR可显著减少肝外疾病风险

HCV的肝外表现是导致许多慢性感染患者发病和死亡的主要原因。现阶段全新的无干扰素全口服抗病毒方案为HCV的治疗带来了突变性进展。

近日研究人员开展系统综述和荟萃研究,对HCV感染者持续病毒学应答(SVR)对肝外疾病的影响进行了考察。

总计48个相关研究参与本次荟萃分析。相比于未实现SVR人群,实现SVR可降低肝外死亡率(OR 0.44,95% CI 0.28-0.67)。SVR患者其冷球蛋白血症血管炎(OR 20.76,6.73-64.05)以及恶性B淋巴细胞增生性疾病(OR 6.49,2.02-20.85)完全缓解率较高。实现SVR可降低随访过程中胰岛素抵抗风险(OR 0.42,0.33-0.53),并降低后续糖尿病发病率(OR 0.34,0.21-0.56)。

研究认为,对于HCV感染人群,抗病毒治疗后实现SVR可显著减少肝外疾病风险。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1257734, encodeId=6e0d125e734a9, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416417, encodeId=fea9141641e70, content=<a href='/topic/show?id=e9b316951a2' target=_blank style='color:#2F92EE;'>#SVR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16951, encryptionId=e9b316951a2, topicName=SVR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f113178185, createdName=w363522450, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473111, encodeId=0d6814e3111df, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311282, encodeId=75d5311282de, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed May 02 10:57:58 CST 2018, time=2018-05-02, status=1, ipAttribution=)]
    2018-05-04 ymljack
  2. [GetPortalCommentsPageByObjectIdResponse(id=1257734, encodeId=6e0d125e734a9, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416417, encodeId=fea9141641e70, content=<a href='/topic/show?id=e9b316951a2' target=_blank style='color:#2F92EE;'>#SVR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16951, encryptionId=e9b316951a2, topicName=SVR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f113178185, createdName=w363522450, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473111, encodeId=0d6814e3111df, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311282, encodeId=75d5311282de, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed May 02 10:57:58 CST 2018, time=2018-05-02, status=1, ipAttribution=)]
    2018-05-04 w363522450
  3. [GetPortalCommentsPageByObjectIdResponse(id=1257734, encodeId=6e0d125e734a9, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416417, encodeId=fea9141641e70, content=<a href='/topic/show?id=e9b316951a2' target=_blank style='color:#2F92EE;'>#SVR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16951, encryptionId=e9b316951a2, topicName=SVR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f113178185, createdName=w363522450, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473111, encodeId=0d6814e3111df, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311282, encodeId=75d5311282de, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed May 02 10:57:58 CST 2018, time=2018-05-02, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1257734, encodeId=6e0d125e734a9, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416417, encodeId=fea9141641e70, content=<a href='/topic/show?id=e9b316951a2' target=_blank style='color:#2F92EE;'>#SVR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16951, encryptionId=e9b316951a2, topicName=SVR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f113178185, createdName=w363522450, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473111, encodeId=0d6814e3111df, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri May 04 01:20:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311282, encodeId=75d5311282de, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed May 02 10:57:58 CST 2018, time=2018-05-02, status=1, ipAttribution=)]
    2018-05-02 忠诚向上

    好好学习天天向上

    0

相关资讯

GUT:哈维尼(ledipasvir/sofosbuvir)可有效治疗HCV4型感染人群

研究证实哈维尼治疗对4型HCV感染者十分有效,其治疗效果不受肝硬化以及先前治疗效果的影响

Hepatol Res:HCV患者采用直接抗病毒药物治疗,肝脏功能和身体组成的变化

研究持续测量了HCV感染患者的身体成分,这些患者接受了DAA治疗,研究发现骨骼肌的数量显著增加,与血清Alb水平和/或体重或VFA的减少有关。但这一结果仅仅出现在低骨骼肌质量的患者中。

J Viral Hepat:采用直接抗病毒药物清除HCV后,肝周淋巴结肿大消失

23.8%的PLEN阳性患者,接受DAA治疗后获得HCV清除后,PLNEs消失。研究需要更长的随访时间来阐明这一现象的临床重要性,尤其是与HCC发展风险的关系。

J Hepatol:HepCom评分,在启动直接抗病毒治疗后,可以检测出高危人群以及相关的临床事件

HepCom评分是Charlson并发症指数、年龄和肝功能(国际标准化比率、白蛋白和胆红素)的组合,在启动直接抗病毒治疗后,可以检测出一组高危人群,以及相关的临床事件。

Liver Int:ombitasvir, paritaprevir/r+dasabuvir+ribavirin治疗HCV基因1b型肝硬化患者的真实疗效和安全性

本研究表明,OBV/PTV/r+DSV+RBV治疗肝硬化患者,具有良好的疗效,SVR为96.6%。与治疗相关的严重不良事件比例为2.9%(61/2070),其中大部分为肝脏功能失代偿(1.9%),与肝功能损害和血小板计数较低相关。

J Hepatol:接受DAA治疗的HCV晚期患者,新发HCC比率不高,可能是先前显微、未发现的肿瘤

大型的、前瞻性、基于人群的研究表明,接受DAAs的晚期丙型肝炎患者中,第一年肝癌的风险并不高,而且可能比未治疗的患者低,并且以后会进一步下降。早期肝癌的出现可能反映了先前存在的、显微的、不可检测的肿瘤。