Hepatol Res:危重症肝硬化患者的急性呼吸窘迫综合征的危险因素和结果

2018-08-31 MedSci MedSci原创

急性肝衰竭和休克是导致ARDS发展的危险因素,而肝硬化和酒精的病因则不是导致ARDS发展的危险因素。患有ARDS的肝硬化患者死亡率明显增加。早期识别和治疗感染对于改善患者的生存是重要的。

研究目的:先前的急性呼吸窘迫综合征的随机对照试验排除了重症肝硬化患者。

有关危重症肝硬化患者的急性呼吸窘迫综合征(ARDS)的危险因素和结果,了解甚少。本研究旨在分析危重患者的ARDS的特征性结果。

研究方法:2012年1月1日至2014年12月31日期间,对肝移植中心重症监护室收治的肝硬化患者进行了观察。采用Berlin定义ARDS。采用多元logistic回归分析ARDS 发生的潜在危险因素。在ARDS 和非-ARDS 患者中,分析住院死亡率等结果。

研究结果:559例患者符合纳入标准,45例(8.1%)发生 ARDS。 ARDS和 非ARDS 患者的差异,包括败血症、终末期肝病模型、钠分和序列器官衰竭评估得分。 患有ARDS的肝硬化患者的住院死亡率高于未患有ARDS的肝硬化患者(82.2% vs. 27.6%, P < 0.001)。多元分析表明,慢加急性肝衰竭(OR 8.69, 95% CI 2.28-33.18, P < 0.01)和休克与ARDS发生相关,肝硬化的病因和饮酒与ARDS无关。

研究结论:急性肝衰竭和休克是导致ARDS发展的危险因素,而肝硬化和酒精的病因则不是导致ARDS发展的危险因素。患有ARDS的肝硬化患者死亡率明显增加。早期识别和治疗感染对于改善患者的生存是重要的。

原始出处

Yang P, Formanek P, Scaglione S, et al. Risk factors and outcomes of acute respiratory distress syndrome in critically ill patients with cirrhosis.Hepatol Res, 2018, Aug 7. doi: 10.1111/hepr.13240.

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    2018-09-02 gwc384
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    2018-08-31 guging

    谢谢!最新的信息读起来就是收获大

    0

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    2018-08-31 医者仁心5538

    学习了

    0

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