Microb Drug Resist:精油的协同抗菌作用或可用于多重耐药菌的治疗

2018-05-02 MedSci MedSci原创

本研究旨在探究几种选定的市售精油和庆大霉素在对抗产超广谱β-内酰胺酶(ESBL)和产新德里金属-β-内酰胺酶-1(NDM-1)肺炎克雷伯菌分离株之间可能产生的协同效应。 通过双盘协同试验证实了产ESBLs。在所测试的菌株中发现了blaNDM-1基因阳性的菌株。使用肺炎克雷伯菌ATCC BAA-1705 TM菌株作为对照。使用方格棋法评估9种精油的协同作用和添加剂作用:香菜,茴香,薄荷,天竺葵

本研究旨在探究几种选定的市售精油和庆大霉素在对抗产超广谱β-内酰胺酶(ESBL)和产新德里金属-β-内酰胺酶-1(NDM-1)肺炎克雷伯菌分离株之间可能产生的协同效应。

通过双盘协同试验证实了产ESBLs。在所测试的菌株中发现了blaNDM-1基因阳性的菌株。使用肺炎克雷伯菌ATCC BAA-1705 TM菌株作为对照。使用方格棋法评估9种精油的协同作用和添加剂作用:香菜,茴香,薄荷,天竺葵,罗勒,丁香,百里香,克拉里鼠尾草和薰衣草,分别与庆大霉素联合使用。

结果表明,薄荷油与庆大霉素联合对对照、产ESBL和产NDM-1分离株均表现出协同抗菌活性。香菜精油与庆大霉素联用对产ESBL和庆大霉素抗性菌株具有协同作用。此外,研究人员还发现,庆大霉素与百里香、茴香、罗勒和鼠尾草鼠尾草也具有协同效应。

综上所述,该研究结果表明,由于精油与庆大霉素的协同活性,特别是薄荷和香菜油,因此这些精油可作为控制多重耐药性感染的替代或附加的治疗选择。

原始出处:

Kwiatkowski P, Pruss A, et al., Preliminary Study on the Antibacterial Activity of Essential Oils Alone and in Combination with Gentamicin Against Extended-Spectrum β-Lactamase-Producing and New Delhi Metallo-β-Lactamase-1-Producing Klebsiella pneumoniae Isolates. Microb Drug Resist. 2018 Apr 30. doi: 10.1089/mdr.2018.0051.

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    2018-12-18 xjy02
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    2018-07-07 wangbingxhy
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  5. 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1857633, encodeId=6641185e63315, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Fri Oct 26 15:49:00 CST 2018, time=2018-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084387, encodeId=7914208438e9f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, 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  7. 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  8. 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createdBy=646d18833414, createdName=lanyan20020092, createdTime=Fri May 04 01:49:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311277, encodeId=926e3112e72b, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed May 02 10:53:27 CST 2018, time=2018-05-02, status=1, ipAttribution=)]
    2018-05-04 skhzy
  9. 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  10. 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createdBy=646d18833414, createdName=lanyan20020092, createdTime=Fri May 04 01:49:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311277, encodeId=926e3112e72b, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed May 02 10:53:27 CST 2018, time=2018-05-02, status=1, ipAttribution=)]
    2018-05-02 忠诚向上

    好好学习天天向上

    0

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本研究旨在测试每种精油(EO),EOs的主要化合物和酶,对抗致病性肺炎克雷伯氏菌的生物膜抑制活性。研究人员探究了七种EOs和三种酶对肺炎克雷伯氏菌生物膜的形成和根除的作用。结果显示薄荷油显示强大的生物膜抑制效果,在5μ/ml时抑菌范围为69.2-98.2%。百里香油具有最佳的生物膜清除能力,在10μl/ml时清除率为80.1-98.0%。通过GC/MS分析最有效的EOs,以确定每种油的主要化学成分