Microb Pathog:植物精油可有效对抗化脓性链球菌

2018-04-08 MedSci MedSci原创

在本研究中,研究人员评价了从牛至、鼠尾草、丁香和生姜中提取的精油(EO)对化脓性链球菌的植物化学特性、抗菌性和抗生物膜活性。使用肉汤微量稀释法测定EOs的最小抑制浓度(MIC)和最小杀菌浓度(MBC)。使用MTT测定确定最小生物膜抑制浓度(MBICs),并通过扫描电子显微镜观察生物膜。牛至和鼠尾草EOs的MIC最小,MBC为0.25-0.5mg/mL。杀菌效力评估试验结果表明,牛至和鼠尾草EOs分

在本研究中,研究人员评价了从牛至、鼠尾草、丁香和生姜中提取的精油(EO)对化脓性链球菌的植物化学特性、抗菌性和抗生物膜活性。

使用肉汤微量稀释法测定EOs的最小抑制浓度(MIC)和最小杀菌浓度(MBC)。使用MTT测定确定最小生物膜抑制浓度(MBICs),并通过扫描电子显微镜观察生物膜。牛至和鼠尾草EOs的MIC最小,MBC为0.25-0.5mg/mL。杀菌效力评估试验结果表明,牛至和鼠尾草EOs分别在5min和4h内表现出杀菌效果。牛至和鼠尾草提取物具有双重作用的有效抗生物膜剂,可预防和根除生物膜。

与未处理的对照相比,使用EOs处理的生物膜出现形态学和密度变化。牛至EO主要由香芹酚构成(91.6%),而在鼠尾草EO中,发现较高水平的α-香芹酮(28.5%)和樟脑(16.6%)。牛至和鼠尾草的Eos可抑制化脓性链球菌的生长和生物膜形成。

综上所述,该研究结果表明,有效浓度的牛至和鼠尾草EOs及其植物化学物质可用于开发潜在的植物源抗菌药物,用于治疗链球菌性咽炎。

原始出处:

Wijesundara NM, Rupasinghe HPV. Essential oils from Origanum vulgare and Salvia officinalis exhibit antibacterial and anti-biofilm activities against Streptococcus pyogenes. Microb Pathog. 2018 Apr;117:118-127. doi: 10.1016/j.micpath.2018.02.026. Epub 2018 Feb 13.  

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    2019-02-18 xjy02
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  5. 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Apr 08 23:37:48 CST 2018, time=2018-04-08, status=1, ipAttribution=)]
  6. 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  7. 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Apr 08 23:37:48 CST 2018, time=2018-04-08, status=1, ipAttribution=)]
    2018-07-25 xuyong535
  8. 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objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96660, encryptionId=69699666026, topicName=链球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787f20641298, createdName=liuquanmn, createdTime=Tue Apr 10 14:31:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745283, encodeId=10801e452834d, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Wed Jul 25 22:31:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304176, 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Apr 08 23:37:48 CST 2018, time=2018-04-08, status=1, ipAttribution=)]
    2018-04-09 lyh994

    天然有效的成分?

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1690315, encodeId=cdf31690315e6, content=<a href='/topic/show?id=c2f63360064' target=_blank style='color:#2F92EE;'>#化脓性链球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33600, encryptionId=c2f63360064, topicName=化脓性链球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdd429030055, createdName=liao1629, createdTime=Sun Jan 20 00:31:00 CST 2019, time=2019-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748172, encodeId=7caf1e481721d, content=<a href='/topic/show?id=129533595e9' target=_blank style='color:#2F92EE;'>#化脓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33595, encryptionId=129533595e9, topicName=化脓性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96660, encryptionId=69699666026, topicName=链球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787f20641298, createdName=liuquanmn, createdTime=Tue Apr 10 14:31:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745283, encodeId=10801e452834d, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Wed Jul 25 22:31:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304176, 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Apr 08 23:37:48 CST 2018, time=2018-04-08, status=1, ipAttribution=)]
    2018-04-09 yfjms

    学习

    0

  10. 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Apr 08 23:37:48 CST 2018, time=2018-04-08, status=1, ipAttribution=)]
    2018-04-08 天地飞扬

    了解一下.谢谢分享!

    0

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