J Prev Med Public Health:孕期叶酸补充有益于预防后代急性淋巴细胞白血病的发生

2019-10-20 不详 网络

J Prev Med Public Health:孕妇补充叶酸对儿童癌症的预防保护作用为防止先天性畸形,几乎每个国家都推荐孕妇补充叶酸。然而,关于母体叶酸摄入与儿童期癌症的相关性知之甚少。因此,本研究旨在确定母体叶酸摄入量对儿童癌症风险的影响。使用标准化关键字从PubMed,Google Scholar,Scopus和ProQuest检索了158篇相关文章,其中17篇纳入了最终评估分析。结果显示,

J Prev Med Public Health:孕妇补充叶酸对儿童癌症的预防保护作用

为防止先天性畸形,几乎每个国家都推荐孕妇补充叶酸。然而,关于母体叶酸摄入与儿童期癌症的相关性知之甚少。因此,本研究旨在确定母体叶酸摄入量对儿童癌症风险的影响。

使用标准化关键字从PubMed,Google Scholar,Scopus和ProQuest检索了158篇相关文章,其中17篇纳入了最终评估分析。

结果显示,11篇文献表明母体补充叶酸与儿童癌症之间存在明显的保护性联系。使用随机效应模型,汇总比值比(OR)显示孕妇叶酸补充与儿童急性淋巴细胞白血病之间存在保护性关联(OR,0.75;95%置信区间[CI],0.66至0.86)。但是,孕妇叶酸补充与儿童急性髓细胞性白血病(OR,0.70; 95%CI,0.46至1.06)或儿童脑瘤(OR,1.02; 95%CI,0.88至1.19)之间没有明显的关联。

综上所述,该研究结果表明,孕妇补充叶酸对儿童急性淋巴细胞白血病具有保护作用。因此,建议医疗保健专业人员就孕期补充叶酸的好处向社区提供定期健康教育和健康促进。
原始出处:

Wan Ismail WR, Abdul Rahman R, et al., The Protective Effect of Maternal Folic Acid Supplementation on Childhood Cancer: A Systematic Review and Meta-analysis of Case-control Studies. J Prev Med Public Health. 2019 Jul;52(4):205-213. doi: 10.3961/jpmph.19.020. Epub 2019 Jul 2.

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    2020-04-11 shizhenshan
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    2019-10-21 txqjm

    谢谢了,学习

    0