Gastroenterology:特异性微生物菌血症导致后继结直肠癌风险增加

2018-05-03 zhangfan MedSci原创

研究发现,以脆弱芽孢杆菌以及溶菌为代表的菌血症患者其后继结肠癌风险增加,这类细菌因肠道功能失调和屏障功能紊乱进入血液。该结果证实了肠道微生物群与结直肠癌发生的相关性

结肠癌患者肠道内脆弱拟杆菌、部分链球菌、梭菌和消化链球菌的比例增加相关。近日研究人员考察了肠道微生物菌血症与结直肠癌之间的关系。

研究在香港开展,收集13096名菌血症住院患者资料,患者基线无肿瘤诊断,考察拟杆菌属,梭菌属,丝状因子属,梭杆菌属,兼性双球菌属,肉芽肿菌属,小微球菌属,消化链球菌属,前球菌属,软杆菌属和链球菌属感染与结肠癌之间的相关性,比较菌血症与非菌血症结肠癌发病的差异。

相比于未感染人群,脆弱芽孢杆菌(HR,3.85;95% CI,2.62-5.64)以及溶菌(HR,5.73;95% CI,2.18-15.1)感染人群的结肠癌风险增加。研究同时发现,核粒梭形杆菌(HR,6.89;95% CI,1.70-27.9)、消化链球菌(HR,3.06;95% CI,1.47-6.35)、败血梭状芽胞杆菌(HR,17.1;95% CI,1.82-160)、产气荚膜梭状芽胞杆菌(HR,2.29;95% CI,1.16-4.52)以及莫比尔氏菌(HR,15.2;95% CI, 1.54-150)感染导致菌血症患者的结肠癌风险增加,而其他微生物感染导致的菌血症不会增加患者结肠癌风险。

研究发现,以脆弱芽孢杆菌以及溶菌为代表的菌血症患者其后继结肠癌风险增加,这类细菌因肠道功能失调和屏障功能紊乱进入血液。该结果证实了肠道微生物群与结直肠癌发生的相关性。

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    2018-12-10 sjq027
  5. 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  6. 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  7. 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    2018-10-24 许安
  8. 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encodeId=2bd23120845a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat May 05 05:46:14 CST 2018, time=2018-05-05, status=1, ipAttribution=)]
    2018-05-07 cscdliu

    学习了.谢谢

    0

  9. 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encodeId=2bd23120845a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat May 05 05:46:14 CST 2018, time=2018-05-05, status=1, ipAttribution=)]
    2018-05-07 大爰

    学习了谢谢分享!!

    0

  10. 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    2018-05-05 121832a9m88暂无昵称

    学习了

    0

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