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Cell Report：阻断Dectin-1信号抑制肥胖及相关炎症和胰岛素耐受

2017-06-16 MedSci MedSci原创

肥胖炎症胰岛素耐受
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Dectin-1是在巨噬细胞和树突状细胞（DC）中高度表达的一种识别真菌细胞壁的β-葡聚糖受体家族的成员。这项研究扩展了Dectin-1的功能，表明，Dectin-1可能是发展肥胖相关炎症和胰岛素耐受的关键因素。阻断Dectin-1可能是治疗与肥胖和胰岛素抵抗相关的慢性炎症的重要治疗靶点。

MyD88蛋白是机体天然免疫系统中重要的蛋白，负责传递病原识别受体（pathogen pattern recognition receptor）所引起的信号。令人惊讶的是，研究人员还发觉MyD88蛋白可以调控肥胖，及脂肪细胞炎症和胰岛素抵抗（insulin resistance）,但是其背后的机制仍然是未知。

在最新上线的Cell report杂志上，Angela Castoldi及其同事报道了他们的发现，敲除MyD88基因的小鼠，在被喂食了高脂饮食后，比野生型小鼠中体重增加的更多，并且产生对于胰岛素的耐受（insulin resistance）。通过分析脂肪组织（adipose tissue）中蛋白质的表达，研究人员发现在肥胖的敲除MyD88基因的小鼠中，Dectin-1蛋白表达升高，并且伴随着促炎性的CD11c + 脂肪组织巨噬细胞的上升。 

研究人员接着通过Dectin-1基因敲除小鼠验证，Dectin-1能够增强饮食诱导的肥胖（diet induced obesity）和胰岛素耐受，并且增加脂肪组织中促炎的CD11c + 巨噬细胞。研究人员通过Dectin-1拮抗剂，阻断了Dectin-1蛋白的信号，改善了喂养高脂饮食所带了来肥胖，及血糖浓度。

Dectin-1是在巨噬细胞和树突状细胞（DC）中高度表达的一种识别真菌细胞壁的β-葡聚糖受体家族的成员。这项研究扩展了Dectin-1的功能，表明，Dectin-1可能是发展肥胖相关炎症和胰岛素耐受的关键因素。阻断Dectin-1可能是治疗与肥胖和胰岛素抵抗相关的慢性炎症的重要治疗靶点。

原始出处：
Angela Castoldi et al. Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88. Cell Reports 19, 2272–2288 June 13, 2017 http://dx.doi.org/10.1016/j.celrep.2017.05.059

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    2018-08-05 娇咩咩

    想知道基因敲除小鼠贵么。。。。

    0

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    2018-02-25 维他命

    #CEL#

    0

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    2018-05-14 baoya

    #胰岛#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=336477, encodeId=85b83364e7b8, content=想知道基因敲除小鼠贵么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/08/02/17d3ec168837bbfd0c770168c3d506ca.jpg, createdBy=cd4a2252507, createdName=娇咩咩, createdTime=Sun Aug 05 01:41:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960268, encodeId=4752196026836, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Feb 25 06:43:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749743, encodeId=db801e49743bd, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon May 14 13:43:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784145, encodeId=8d231e8414558, content=<a href='/topic/show?id=5562580e8d' target=_blank style='color:#2F92EE;'>#dectin-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5807, encryptionId=5562580e8d, topicName=dectin-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Mon Apr 30 21:43:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710076, encodeId=6afd1e1007600, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Tue Nov 21 03:43:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870009, encodeId=45cb18e00092a, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon May 21 20:43:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216977, encodeId=32c82169e7ba, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Fri Jun 30 07:11:26 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216501, encodeId=d612216501b8, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Thu Jun 29 05:28:35 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216246, encodeId=5a4621624634, content=学海无涯苦作舟, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Wed Jun 28 08:02:58 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215753, encodeId=f337215e53c3, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Tue Jun 27 05:15:31 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2018-04-30 chaojitidian

    #dectin-1#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=336477, encodeId=85b83364e7b8, content=想知道基因敲除小鼠贵么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/08/02/17d3ec168837bbfd0c770168c3d506ca.jpg, createdBy=cd4a2252507, createdName=娇咩咩, createdTime=Sun Aug 05 01:41:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960268, encodeId=4752196026836, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Feb 25 06:43:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749743, encodeId=db801e49743bd, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon May 14 13:43:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784145, encodeId=8d231e8414558, content=<a href='/topic/show?id=5562580e8d' target=_blank style='color:#2F92EE;'>#dectin-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5807, encryptionId=5562580e8d, topicName=dectin-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Mon Apr 30 21:43:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710076, encodeId=6afd1e1007600, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Tue Nov 21 03:43:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870009, encodeId=45cb18e00092a, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon May 21 20:43:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216977, encodeId=32c82169e7ba, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Fri Jun 30 07:11:26 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216501, encodeId=d612216501b8, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Thu Jun 29 05:28:35 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216246, encodeId=5a4621624634, content=学海无涯苦作舟, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Wed Jun 28 08:02:58 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215753, encodeId=f337215e53c3, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Tue Jun 27 05:15:31 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-11-21 41514497@qq.com

    #阻断#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=336477, encodeId=85b83364e7b8, content=想知道基因敲除小鼠贵么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/08/02/17d3ec168837bbfd0c770168c3d506ca.jpg, createdBy=cd4a2252507, createdName=娇咩咩, createdTime=Sun Aug 05 01:41:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960268, encodeId=4752196026836, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Feb 25 06:43:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749743, encodeId=db801e49743bd, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon May 14 13:43:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784145, encodeId=8d231e8414558, content=<a href='/topic/show?id=5562580e8d' target=_blank style='color:#2F92EE;'>#dectin-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5807, encryptionId=5562580e8d, topicName=dectin-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Mon Apr 30 21:43:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710076, encodeId=6afd1e1007600, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Tue Nov 21 03:43:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870009, encodeId=45cb18e00092a, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon May 21 20:43:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216977, encodeId=32c82169e7ba, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Fri Jun 30 07:11:26 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216501, encodeId=d612216501b8, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Thu Jun 29 05:28:35 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216246, encodeId=5a4621624634, content=学海无涯苦作舟, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Wed Jun 28 08:02:58 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215753, encodeId=f337215e53c3, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Tue Jun 27 05:15:31 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2018-05-21 zhaozhouchifen

    #Cell#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=336477, encodeId=85b83364e7b8, content=想知道基因敲除小鼠贵么。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/08/02/17d3ec168837bbfd0c770168c3d506ca.jpg, createdBy=cd4a2252507, createdName=娇咩咩, createdTime=Sun Aug 05 01:41:22 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960268, encodeId=4752196026836, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Feb 25 06:43:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749743, encodeId=db801e49743bd, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon May 14 13:43:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784145, encodeId=8d231e8414558, content=<a href='/topic/show?id=5562580e8d' target=_blank style='color:#2F92EE;'>#dectin-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5807, encryptionId=5562580e8d, topicName=dectin-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Mon Apr 30 21:43:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710076, encodeId=6afd1e1007600, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, createdName=41514497@qq.com, createdTime=Tue Nov 21 03:43:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870009, encodeId=45cb18e00092a, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon May 21 20:43:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216977, encodeId=32c82169e7ba, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Fri Jun 30 07:11:26 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216501, encodeId=d612216501b8, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Thu Jun 29 05:28:35 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216246, encodeId=5a4621624634, content=学海无涯苦作舟, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Wed Jun 28 08:02:58 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215753, encodeId=f337215e53c3, content=不断学习不断进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95d11946707, createdName=1e104401m00(暂无匿称), createdTime=Tue Jun 27 05:15:31 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-30 1e104401m00(暂无匿称)

    不断学习不断进步

    0

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    2017-06-29 1e104401m00(暂无匿称)

    不断学习不断进步

    0

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    2017-06-28 1e104401m00(暂无匿称)

    学海无涯苦作舟

    0

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    2017-06-27 1e104401m00(暂无匿称)

    不断学习不断进步

    0

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