J CLIN ENDOCR METAB:糖尿病并发症指向上升的痴呆风险

2015-07-14 佚名 生物谷

根据发表在The Journal of Clinical Endocrinology & Metabolism的一篇研究,患有糖尿病和诸多糖尿病并发症的患者在老年时期更容易患痴呆症,相比于并发症较少的糖尿病患者。 糖尿病患者胰腺不能产生足够胰岛素,或身体不能有效率地利用胰岛素处理多余的糖。如果糖尿病未能控制,血糖长期处于高水平状态下,会发生严重的并发症,包括失明,肾功能衰竭,四肢血流减少

根据发表在The Journal of Clinical Endocrinology & Metabolism的一篇研究,患有糖尿病和诸多糖尿病并发症的患者在老年时期更容易患痴呆症,相比于并发症较少的糖尿病患者。

糖尿病患者胰腺不能产生足够胰岛素,或身体不能有效率地利用胰岛素处理多余的糖。如果糖尿病未能控制,血糖长期处于高水平状态下,会发生严重的并发症,包括失明,肾功能衰竭,四肢血流减少甚至截肢。美国有超过29万人患有糖尿病。而每100位糖尿病患者中,21位有神经损伤,27位有糖尿病肾病,29至33人患有糖尿病视网膜病变。

国立台湾大学公共卫生学院的Wei-Che Chiu教授领导他的团队进行了第一个全国性的研究,探讨糖尿病的轻重和进展与老年痴呆症诊断率之间的关联。

在长达12年之久的人群队列研究中,研究人员使用了台湾全民健康保险研究资料库的记录,从1999年记录开始,找到431178位年龄50岁以上,新诊断的糖尿病患者。研究人员统计分析记录,确认有多少人在被诊断之后送往医院或至少有三个痴呆症门诊记录。为了评估每个人的糖尿病的进展,研究人员使用了糖尿病并发症的严重程度指数(aDCSI),用于预测糖尿病人的死亡率和住院率。

在队列中,共有26856人(6.2%)的患者被诊断为老年痴呆症。糖尿病并发症严重指数高的患者患痴呆症的风险也明显较高。指数评分为1,2,3和大于3的患者换痴呆症的风险分别是1.04,1.40,1.54和1.7 (P<0.001).

这项研究表明糖尿病患者的血糖控制为何如此重要。及时控制血糖发展和糖尿病进程可能有助于防止未来生活中痴呆症的发作。

原始出处

Chiu WC1, Ho WC1, Liao DL1, Lin MH1, Chiu CC1, Su YP1, Chen PC1.Progress of Diabetic Severity and Risk of Dementia.J Clin Endocrinol Metab. 2015 Jul

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    2016-04-14 一闲
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    2015-08-14 guojianrong
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    2015-08-06 hlycom3356

    期待有更多研究

    0

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    2015-12-08 丁鹏鹏
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