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Clin Chem：循环游离DNA中的5-羟甲基胞嘧啶揭示了2型糖尿病血管并发症

2019-12-23 MedSci MedSci原创

2型糖尿病血管并发症
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如大血管和微血管事件等2型糖尿病(T2D)的长期并发症是T2D相关残疾和死亡的主要原因。如果有一种临床上操作方便、无创的方法来监测这些并发症的发展，将提高T2D患者的整体生活质量，并通过预防干预措施帮助减轻医疗负担。

如大血管和微血管事件等2型糖尿病(T2D)的长期并发症是T2D相关残疾和死亡的主要原因。如果有一种临床上操作方便、无创的方法来监测这些并发症的发展，将提高T2D患者的整体生活质量，并通过预防干预措施帮助减轻医疗负担。

本研究采用5-羟甲基胞嘧啶(5hmC-Seal)选择性化学标记策略，从中国患者(n = 62)的循环游离DNA (cfDNA)中提取5hmCs，这是一种新兴的表观遗传标记，涉及糖尿病等复杂疾病。采用病例对照设计，分析T2D合并大血管/微血管并发症和未合并大血管/微血管并发症患者之间差异修饰的5hmC标志物。

研究结果显示，5hmC标志物的变化与t2d相关的大血管/微血管并发症相关，涉及血管生物学和糖尿病相关的基因和通路，包括胰岛素抵抗和炎症，具有统计学意义。一个16基因的5hmC标记板可以准确地将血管并发症患者与那些没有区分开来[测试集:曲线下面积(AUC) = 0.85;95% CI, 0.73-0.96]，优于传统的临床变量如尿白蛋白。另外，一个单独的13基因5hmC标记板可以区分单一并发症患者和多重并发症患者(检测集:AUC = 0.84;95% CI(0.68-0.99)，优于常规临床变量。

研究表明，cfDNA中5hmC标记物反映了T2D大血管/微血管并发症患者的表观遗传变化。5hmC-Seal试验有可能成为一种临床方便、无创的方法，可用于临床监测糖尿病血管并发症的存在和严重程度。

原始出处：

Ying Yang, Chang Zeng,5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes

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    2020-09-23 丁鹏鹏

    #并发#

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    2020-09-03 654699882_84926986

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    2020-11-11 shock_melon

    #循环游离DNA#

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    2019-12-25 ms3892185887221420

    #血管并发症#

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    2019-12-25 LSJ116

    #游离DNA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1758188, encodeId=81841e5818868, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Sep 23 03:22:00 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809515, encodeId=48fe180951545, content=<a href='/topic/show?id=7fd283e596f' target=_blank style='color:#2F92EE;'>#胞嘧啶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83759, encryptionId=7fd283e596f, topicName=胞嘧啶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Thu Sep 03 18:22:00 CST 2020, time=2020-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722255, encodeId=0f3a1e2225510, content=<a href='/topic/show?id=836b50442c9' target=_blank style='color:#2F92EE;'>#循环游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50442, encryptionId=836b50442c9, topicName=循环游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859433239718, createdName=shock_melon, createdTime=Wed Nov 11 23:22:00 CST 2020, time=2020-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545371, encodeId=e97915453e18e, content=<a href='/topic/show?id=a803896303f' target=_blank style='color:#2F92EE;'>#血管并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89630, encryptionId=a803896303f, topicName=血管并发症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b67913724176, createdName=ms3892185887221420, createdTime=Wed Dec 25 12:22:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573586, encodeId=f6ae15e3586a8, content=<a href='/topic/show?id=ad6066363fb' target=_blank style='color:#2F92EE;'>#游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66363, encryptionId=ad6066363fb, topicName=游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d04c15907611, createdName=LSJ116, createdTime=Wed Dec 25 12:22:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042877, encodeId=bdae10428e74c, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Dec 24 00:22:00 CST 2019, time=2019-12-24, status=1, ipAttribution=)]
    2019-12-24 misszhang

    谢谢MedSci提供最新的资讯

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