PLoS One：雌激素可能降低老年女性糖尿病患者发生缺血性卒中的风险

2016-01-23 MedSci译 MedSci原创

本研究旨在探讨缺血性卒中风险和55岁以上糖尿病女性患者结合雌激素（CEE）使用之间可能存在的联系。从台湾国家健康保险系统中收集2003到2009年间，使用CEE 55岁以上糖尿病女性患者（每天0.625毫克）428例。为了进行比较，21026名来自同一个队列没有使用雌激素的糖尿病女性患者作为对照组，排除存在缺血性卒中史的患者。应用倾向评分方法按照1:3的比例确定为对照组（n = 1284）。倾向评

本研究旨在探讨缺血性卒中风险和55岁以上糖尿病女性患者结合雌激素（CEE）使用之间可能存在的联系。

从台湾国家健康保险系统中收集2003到2009年间，使用CEE 55岁以上糖尿病女性患者（每天0.625毫克）428例。为了进行比较，21026名来自同一个队列没有使用雌激素的糖尿病女性患者作为对照组，排除存在缺血性卒中史的患者。应用倾向评分方法按照1:3的比例确定为对照组（n = 1284）。倾向评分匹配协变量包括年龄和共发病。应用Cox比例风险模型估计CEE与缺血性脑卒中的关系。

与对照组相比，使用CEE的患者缺血性卒中的发生率明显降低（0.9% VS 3%，P = 0.016相比）。采用Cox比例风险模型进一步分析显示，在校正了年龄、共发病、社会经济状况、城市化，与缺血性卒中相关的其他药物，使用CEE患者发生卒中的风险较低（HR：0.34；95%CI：0.12-0.97）。因为数据库的性质, 不能确定更年期的时间。

CEE可能降低55岁以上女性糖尿病患者发生缺血性卒中的风险。

原文出处：

Chen YH, Hsieh TF, et al. Estrogen Therapy and Ischemic Stroke in Women with Diabetes Aged Over 55 Years: A Nation-Wide Prospective Population-Based Study in Taiwan. PLoS One. 2015 Dec 14.

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2016-03-24 guihongzh

#缺血性#

42 0
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2016-03-20 忠诚向上

仔细阅读，好好品味

115 0
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2016-03-20 忠诚向上

仔细阅读，好好品味

132 0
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2016-03-20 忠诚向上

仔细阅读，好好品味

110 0
[GetPortalCommentsPageByObjectIdResponse(id=1892721, encodeId=80bf1892e21d0, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Mar 24 16:55:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71756, encodeId=c9e6e175645, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:24:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71747, encodeId=f356e17473e, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71748, encodeId=97c8e1748c9, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71749, encodeId=15ebe174998, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71750, encodeId=6a53e17507d, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71751, encodeId=2c07e175161, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71754, encodeId=7b8de1754db, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71755, encodeId=15bbe1755bf, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71752, encodeId=71dbe17528a, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=)]
2016-03-20 忠诚向上

仔细阅读，好好品味

51 0
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2016-03-20 忠诚向上

仔细阅读，好好品味

97 0
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2016-03-20 忠诚向上

仔细阅读，好好品味

92 0
[GetPortalCommentsPageByObjectIdResponse(id=1892721, encodeId=80bf1892e21d0, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Mar 24 16:55:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71756, encodeId=c9e6e175645, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:24:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71747, encodeId=f356e17473e, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71748, encodeId=97c8e1748c9, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71749, encodeId=15ebe174998, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71750, encodeId=6a53e17507d, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71751, encodeId=2c07e175161, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71754, encodeId=7b8de1754db, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71755, encodeId=15bbe1755bf, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71752, encodeId=71dbe17528a, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=)]
2016-03-20 忠诚向上

仔细阅读，好好品味

106 0
[GetPortalCommentsPageByObjectIdResponse(id=1892721, encodeId=80bf1892e21d0, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Mar 24 16:55:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71756, encodeId=c9e6e175645, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:24:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71747, encodeId=f356e17473e, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71748, encodeId=97c8e1748c9, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71749, encodeId=15ebe174998, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71750, encodeId=6a53e17507d, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71751, encodeId=2c07e175161, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71754, encodeId=7b8de1754db, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71755, encodeId=15bbe1755bf, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=71752, encodeId=71dbe17528a, content=仔细阅读，好好品味, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Mar 20 07:23:00 CST 2016, time=2016-03-20, status=1, ipAttribution=)]
2016-03-20 忠诚向上

仔细阅读，好好品味

76 0
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2016-03-20 忠诚向上

仔细阅读，好好品味

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