MHR:生育治疗的新希望-人类卵子可在实验室成熟

2018-02-10 榕榕 来宝网

人类的卵子已经可以在实验室生长,这可能会导致生育力的改善。

人类的卵子已经可以在实验室生长,这可能会导致生育力的改善。

科学家们已经研发出卵细胞,卵细胞在发育的最早阶段从卵巢组织中被移除,直到它们到受精的程度。

这种进步可以保护带有癌症的女孩的生育能力,从而在可能有害的医疗治疗(如化疗)之前进行。从病人的卵巢组织中回收的未成熟的卵可以在实验室成熟,并储存以备后续。

传统上,癌症患者可以在治疗之前取出一块卵巢,但是重新植入该组织可能会导致癌症的再次引发。

该研究还对人类卵子在不同阶段如何发育提供了深入的见解,有助于研究其他不孕症的治疗和再生医学。

科学家和医学专家共同合作开发可生长卵子的合适物质 - 称为培养基 - 以支持细胞发育的各个阶段。他们的研究结果,使用正在接受常规手术的妇女捐赠的组织,建立在30年的研究基础上。


在以前的研究中,科学家们开发了小鼠卵子来生产活的后代。最新研究是第一次将人类卵子在实验室从最早阶段发展到完全成熟的。

该研究与爱丁堡皇家医院,纽约人类生殖中心和爱丁堡皇家儿童医院合作进行,得到了医学研究委员会的支持。它发表在分子人类生殖上。

负责这项研究的生物科学学院的Evelyn Telfer教授说:“能够在实验室充分利用人类的卵子可以扩大现有生育能力的范围,我们正在努力优化支持卵子发育的条件,我们也希望能够通过监管部门的批准,了解他们是否能够受精。”

原始出处:

S.F. Rinaldi, S Makieva, P.T. Saunders, et al. Immune cell and transcriptomic analysis of the human decidua in term and preterm parturition. MHR: Basic science of reproductive medicine, Volume 23, Issue 10, 1 October 2017, Pages 708–724.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1745928, encodeId=9f141e459281f, content=<a href='/topic/show?id=f46669580f4' target=_blank style='color:#2F92EE;'>#生育治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69580, encryptionId=f46669580f4, topicName=生育治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a135628396, createdName=3631185, createdTime=Fri May 04 16:41:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969969, encodeId=5bcd196996947, content=<a href='/topic/show?id=ec345834075' target=_blank style='color:#2F92EE;'>#新希望#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58340, encryptionId=ec345834075, topicName=新希望)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Tue Jun 19 09:41:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522327, encodeId=054d152232ea1, content=<a href='/topic/show?id=d36d3681414' target=_blank style='color:#2F92EE;'>#卵子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36814, encryptionId=d36d3681414, topicName=卵子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73f511449037, createdName=zlawrance, createdTime=Sun Feb 11 23:41:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286771, encodeId=9203286e71d6, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Sat Feb 10 10:17:37 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286737, encodeId=7a77286e3792, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Feb 10 08:52:23 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
    2018-06-19 珙桐
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    2018-02-11 zlawrance
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    2018-02-10 飘飘爱

    很好

    0

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    2018-02-10 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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