Transplantation:患者脆弱性与肾移植后健康相关生活质量的相关性分析

2018-08-11 佚名 循医医学之窗

健康相关生活质量(HRQOL)可反映患者疾病负担、治疗疗效及健康状态,是终末期肾病(ESRD)患者生理心理因素及肾病特异性评分的综合体现。一般而言,肾移植(KT)后,患者HRQOL改善;但患者脆弱性则可导致预后不良。

健康相关生活质量(HRQOL)可反映患者疾病负担、治疗疗效及健康状态,是终末期肾病(ESRD)患者生理心理因素及肾病特异性评分的综合体现。一般而言,肾移植(KT)后,患者HRQOL改善;但患者脆弱性则可导致预后不良。目前脆弱性KT受者在KT后HRQOL改善程度是否与非脆弱性受者类似还不得而知。为此,美国约翰?霍普金斯医学院的专家进行了一项前瞻性、多中心纵向队列研究,明确了KT前患者脆弱性与KT后HRQOL改善程度的相关性。

本前瞻性多中心纵向队列研究共纳入443例于2014年5月~2017年5月间在约翰?霍普金斯医院与密西根大学医院接受KT的受者;采用肾脏疾病生活质量简表(KDQOL-SF)明确患者脆弱性、生理心理状态以及肾病特异性HRQOL。采用校正后的混合线性回归模型,明确KT后短期内(KT后3个月),患者脆弱状态相关HRQOL变化率。

结果发现,这些患者的平均年龄为52.0±14.1岁(范围:19.9~86.0);37.0%为脆弱/中度脆弱患者;KT后中位随访时间为7.7个月。患者KT时的生理相关HRQOL评分均值为43.3±9.6分,心理相关HRQOL评分均值为52.8±8.9分,肾病特异性HRQOL评分均值为72.6±12.8分。KT时,脆弱KT受者较非脆弱受者的生理相关HRQOL评分(39.3 vs 45.6,P<0.001)及肾病特异性HRQOL评分(70.2 vs 76.1,P<0.001)显着降低,而心理相关HRQOL评分则无显着差异(52.4 vs 53.1,P=0.43)。经受者与供者因素校正后的回归模型分析显示,与非脆弱受者相比,脆弱受者生理相关HRQOL评分与肾病特异性HRQOL评分改善程度显着增高,分别为0.34分/月[95%置信区间(CI):-0.17~1.25]vs 1.35分/月(95%CI:0.65~2.05)(P=0.02)与2.41分/月(95%CI:1.78~3.04)vs 3.75分/月(95%CI:2.89~4.60)(P=0.01)(图1),而心理相关HRQOL评分改善程度则无差异[0.46分/月(95%CI:-0.06~0.98)vs 0.54分/月(95%CI:-0.17~1.25);P=0.85]。


图1. 脆弱与非脆弱KT受者在移植后3个月期间HRQOL评分改善程度比较

翻译:HRQOLimprovement:HRQOL评分改善程度;Mean change Score (3months-KT):肾移植后3个月HQROL评分;physical HRQOL:生理相关HRQOL;Mental HRQOL:心理相关HRQOL;kidney disease-specific HRQOL:肾病特异性HRQOL。

综上所述,本研究表明,对于脆弱KT受者等高风险患者而言,接受KT仍可实现HRQOL获益,这对KT候选患者的选择具有重要意义;KT可改善脆弱患者或对透析不耐受患者的生理相关及肾病特异性HRQOL。

原始出处:McAdams-DeMarco MA1,2, Olorundare IO1, Ying H1, et al. Frailty and Postkidney Transplant Health-Related Quality of Life. Transplantation. 2018 Feb;102(2):291-299.

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style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sat Jan 26 08:08:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522191, encodeId=26b81522191cb, content=<a href='/topic/show?id=d08e2e894e7' target=_blank style='color:#2F92EE;'>#健康相关生活质量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27894, encryptionId=d08e2e894e7, topicName=健康相关生活质量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0411427202, createdName=yilong5287546, createdTime=Mon Aug 13 09:08:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=338090, encodeId=d93d338090e8, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 12 08:00:30 CST 2018, time=2018-08-12, status=1, ipAttribution=)]
    2018-08-27 bsmagic9140
  5. 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style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sat Jan 26 08:08:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522191, encodeId=26b81522191cb, content=<a href='/topic/show?id=d08e2e894e7' target=_blank style='color:#2F92EE;'>#健康相关生活质量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27894, encryptionId=d08e2e894e7, topicName=健康相关生活质量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0411427202, createdName=yilong5287546, createdTime=Mon Aug 13 09:08:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=338090, encodeId=d93d338090e8, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 12 08:00:30 CST 2018, time=2018-08-12, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1837550, encodeId=bd96183e55076, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Nov 13 08:08:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796145, encodeId=958f1e9614541, content=<a href='/topic/show?id=691c1e765a0' target=_blank style='color:#2F92EE;'>#Transplant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17765, encryptionId=691c1e765a0, topicName=Transplant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Sun Nov 25 11:08:00 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933534, encodeId=9208193353426, content=<a href='/topic/show?id=809b1e7664f' target=_blank style='color:#2F92EE;'>#Transplantation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17766, encryptionId=809b1e7664f, topicName=Transplantation)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Fri Feb 22 19:08:00 CST 2019, time=2019-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657051, encodeId=50d1165e05140, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, 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style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sat Jan 26 08:08:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522191, encodeId=26b81522191cb, content=<a href='/topic/show?id=d08e2e894e7' target=_blank style='color:#2F92EE;'>#健康相关生活质量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27894, encryptionId=d08e2e894e7, topicName=健康相关生活质量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0411427202, createdName=yilong5287546, createdTime=Mon Aug 13 09:08:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=338090, encodeId=d93d338090e8, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 12 08:00:30 CST 2018, time=2018-08-12, status=1, ipAttribution=)]
    2019-01-26 xuyu
  7. 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GetPortalCommentsPageByObjectIdResponse(id=338090, encodeId=d93d338090e8, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 12 08:00:30 CST 2018, time=2018-08-12, status=1, ipAttribution=)]
  8. 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  9. 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GetPortalCommentsPageByObjectIdResponse(id=338090, encodeId=d93d338090e8, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Aug 12 08:00:30 CST 2018, time=2018-08-12, status=1, ipAttribution=)]
    2018-08-12 1237a7a1m07暂无昵称

    这个有大数据

    0

  10. 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    2018-08-12 131****1460

    学习了受益匪浅

    0

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