Pediatrics:库欣综合征患儿在治疗后自杀的风险增加

2016-03-30 MedSci MedSci原创

根据美国国家卫生研究院的一项研究,库欣综合症的儿童有较高的自杀的风险,并且在疾病成功治愈后还会长期存在抑郁,焦虑等心理健康状况。库欣综合征是由于高水平的激素皮质醇引起的。该综合征的长期并发症包括肥胖,糖尿病,骨折,高血压,肾结石和严重感染。库欣综合征可通过肾上腺肿瘤或身体其他部位产生过量皮质醇引起的。它也可能是由于刺激肾上腺产生高皮质醇水平的垂体肿瘤引起的。治疗通常包括通过切除肿瘤停止产生过量的皮

根据美国国家卫生研究院的一项研究,库欣综合症的儿童有较高的自杀的风险,并且在疾病成功治愈后还会长期存在抑郁,焦虑等心理健康状况。

库欣综合征是由于高水平的激素皮质醇引起的。该综合征的长期并发症包括肥胖,糖尿病,骨折,高血压,肾结石和严重感染。库欣综合征可通过肾上腺肿瘤或身体其他部位产生过量皮质醇引起的。它也可能是由于刺激肾上腺产生高皮质醇水平的垂体肿瘤引起的。治疗通常包括通过切除肿瘤停止产生过量的皮质醇。

“我们的研究结果表明,护理库欣综合征年轻患者的医生应该筛查病人在疾病成功治愈后是否有潜在抑郁症有关的精神疾病,”美国国家卫生研究院尤妮斯甘乃迪施莱佛儿童健康与人类发展国家研究所国内人口健康研究部主任,这项研究的主要作者,Constantine Stratakis, D(med)Sci说。“患者可能不告诉他们的医生,他们感到沮丧,所以对于医生主动评估病人的抑郁症和相关状况是一个非常好的想法。”

库欣综合征会影响到成人和儿童。最近的一项研究估计,在美国,每年每100万人就有8例库欣综合征患者。

研究人员在Pediatrics杂志上发表了他们的发现。他们在NIH筛查了从2003年到2014年之间治疗的所有儿童和青年的病历,一共有149例库新综合征患者。研究人员发现,治疗数个月后,9名儿童(约6%)有自杀的念头和愤怒,抑郁,易怒和焦虑的爆发经历。其中,在他们治疗的7个月内, 7名儿童经历了这些症状。另外2人在治疗后至少48个月开始出现症状。

作者指出,库欣综合征患儿往往有强迫行为,往往成为学校的优等生。治疗后,但是,他们又变得沮丧和焦虑。这与库欣综合征成年患者相反,他们往往在治疗前变得沮丧和焦虑,但在治疗后会逐步克服这些症状。

作者指出,卫生保健提供者应尝试为那些库欣综合征的儿童在治疗前做一些准备,让他们知道他们的心情可能在手术后发生变化,可能在几个月或几年都不会改善。同样,这些卫生保健工作者应考虑定期筛查这些患者,筛查哪些患者在他们的年治疗后自杀的危险。

原始出处:

Margaret F. Keil, Alan Zametkin, Celia Ryder,et al.Cases of Psychiatric Morbidity in Pediatric Patients After Remission of Cushing Syndrome,Pediatrics,2016.3.30

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    2016-12-05 feather89
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    2016-06-07 hbwxf
  4. [GetPortalCommentsPageByObjectIdResponse(id=1637305, encodeId=4e07163e3057c, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Dec 17 13:59:00 CST 2016, time=2016-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726065, encodeId=95fe1e2606588, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 05 10:59:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958464, encodeId=a06819584644e, content=<a href='/topic/show?id=766713993a1' target=_blank style='color:#2F92EE;'>#Pediatric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13993, encryptionId=766713993a1, topicName=Pediatric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Jun 07 21:59:00 CST 2016, time=2016-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79982, encodeId=6c9be9982ee, content=i看看看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:26:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79983, encodeId=a20ce9983ea, content=哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:26:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79976, encodeId=ce25e997691, content=Hhh, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79977, encodeId=aea7e9977e7, content=Nnnnnnn, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79978, encodeId=5958e997846, content=Njjnnk, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79979, encodeId=551ae997954, content=Mmmmmm, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79980, encodeId=2277e998022, content=Lkllll, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=)]
    2016-04-21 三毛坨

    i看看看看

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1637305, encodeId=4e07163e3057c, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Dec 17 13:59:00 CST 2016, time=2016-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726065, encodeId=95fe1e2606588, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 05 10:59:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958464, encodeId=a06819584644e, content=<a href='/topic/show?id=766713993a1' target=_blank style='color:#2F92EE;'>#Pediatric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13993, encryptionId=766713993a1, topicName=Pediatric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Jun 07 21:59:00 CST 2016, time=2016-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79982, encodeId=6c9be9982ee, content=i看看看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:26:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79983, encodeId=a20ce9983ea, content=哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:26:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79976, encodeId=ce25e997691, content=Hhh, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79977, encodeId=aea7e9977e7, content=Nnnnnnn, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79978, encodeId=5958e997846, content=Njjnnk, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79979, encodeId=551ae997954, content=Mmmmmm, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79980, encodeId=2277e998022, content=Lkllll, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=)]
    2016-04-21 三毛坨

    哈哈哈哈

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1637305, encodeId=4e07163e3057c, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Dec 17 13:59:00 CST 2016, time=2016-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726065, encodeId=95fe1e2606588, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 05 10:59:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958464, encodeId=a06819584644e, content=<a href='/topic/show?id=766713993a1' target=_blank style='color:#2F92EE;'>#Pediatric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13993, encryptionId=766713993a1, topicName=Pediatric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Jun 07 21:59:00 CST 2016, time=2016-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79982, encodeId=6c9be9982ee, content=i看看看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:26:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79983, encodeId=a20ce9983ea, content=哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:26:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79976, encodeId=ce25e997691, content=Hhh, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79977, encodeId=aea7e9977e7, content=Nnnnnnn, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79978, encodeId=5958e997846, content=Njjnnk, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79979, encodeId=551ae997954, content=Mmmmmm, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79980, encodeId=2277e998022, content=Lkllll, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=)]
    2016-04-21 三毛坨

    Hhh

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1637305, encodeId=4e07163e3057c, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Dec 17 13:59:00 CST 2016, time=2016-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726065, encodeId=95fe1e2606588, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Dec 05 10:59:00 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958464, encodeId=a06819584644e, content=<a href='/topic/show?id=766713993a1' target=_blank style='color:#2F92EE;'>#Pediatric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13993, encryptionId=766713993a1, topicName=Pediatric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Jun 07 21:59:00 CST 2016, time=2016-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79982, encodeId=6c9be9982ee, content=i看看看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:26:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79983, encodeId=a20ce9983ea, content=哈哈哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:26:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79976, encodeId=ce25e997691, content=Hhh, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79977, encodeId=aea7e9977e7, content=Nnnnnnn, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79978, encodeId=5958e997846, content=Njjnnk, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79979, encodeId=551ae997954, content=Mmmmmm, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79980, encodeId=2277e998022, content=Lkllll, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43f41674911, createdName=三毛坨, createdTime=Thu Apr 21 16:25:00 CST 2016, time=2016-04-21, status=1, ipAttribution=)]
    2016-04-21 三毛坨

    Nnnnnnn

    0

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    2016-04-21 三毛坨

    Njjnnk

    0

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    2016-04-21 三毛坨

    Mmmmmm

    0

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    2016-04-21 三毛坨

    Lkllll

    0

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