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Molecules：草花总黄酮或可用于治疗阿尔茨海默病

2013-03-26 中科院新疆理化技术研究所 丁香园

草花总黄酮阿尔茨海默病
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草花总黄酮对细胞存活的保护作用 阿尔茨海默病(Alzheimer’S disease，AD)是一种多发于中老年期的中枢神经系统退行性疾病，也是我们常说的老年痴呆症，患者典型的临床症状为进行性的记忆障碍和认知功能不断恶化，日常生活能力进行性减退，并具有各种神经症状和行为障碍。伴随社会老龄化的进程，AD的发病率逐年上升，已经成为严重的社会问题。 中科院新疆理化技术研究所资源化学研究室科研人员从


草花总黄酮对细胞存活的保护作用
阿尔茨海默病(Alzheimer’S disease，AD)是一种多发于中老年期的中枢神经系统退行性疾病，也是我们常说的老年痴呆症，患者典型的临床症状为进行性的记忆障碍和认知功能不断恶化，日常生活能力进行性减退，并具有各种神经症状和行为障碍。伴随社会老龄化的进程，AD的发病率逐年上升，已经成为严重的社会问题。
中科院新疆理化技术研究所资源化学研究室科研人员从棉花的花瓣中提取纯化制成的有效部位——草花总黄酮，经研究发现该有效部位可用于抗老年痴呆的研究，目前该研究室已完成了草花有效部位抗老年痴呆临床前研究工作，包括草花药材指纹图谱、薄层鉴别项和含量测定项、草花总黄酮片剂的成型工艺研究、草花原料药、制剂的质量标准和对照品的制备工艺以及草花总黄酮片加速稳定实验和长期稳定实验等，正在进行天然药五类新药的申报。
通过对草花总黄酮有效部分及其黄酮类化合物进行了抗氧化活性和乙酰胆碱酯酶活性的研究，科研人员又发现该有效部位及其黄酮类化合物不仅具有清除自由基的抗氧化活性，而且也具有一定的乙酰胆碱酯酶抑制活性，同时草花总黄酮及部分黄酮类化合物还具有保护氧化应激引起的PC12细胞损伤作用，该研究为草花总黄酮对老年痴呆的治疗提供了重要的理论依据。
该研究成果以Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium Herbaceam为题，发表在Molecules上。

Abstract: Our previous research showed that standardized extract from the flowers of the Gossypium herbaceam labeled GHE had been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementia and Alzheimer’s disease (AD). The aim of this work was to determine the components of this herb and the individual constituents of GHE. In order to better understand this herb for AD treatment, we investigated the acetylcholinesterase (AChE) inhibition and antioxidant activity of GHE as well as the protective effects to PC12 cells against cytotoxicity induced by tertiary butyl hydroperoxide (tBHP) using in vitro assays. The antioxidant activities were assessed by measuring their capabilities for scavenging 1,1-diphenyl-2-picylhydrazyl (DPPH) and 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical as well as in inhibiting lipid peroxidation. Our data showed that GHE exhibited certain activities against AChE and also is an efficient free radical scavenger, which may be helpful in preventing or alleviating patients suffering from AD.

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    2013-06-26 ms1948154235210413

    #阿尔茨#

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    2013-10-26 fengyi821

    #黄酮#

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    2014-03-02 12498da4m32(暂无昵称)

    #阿尔茨海#

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    2013-03-28 yhj-time

    #阿尔茨海默#

    0