Neural Regen Res. ：人参皂苷Rg1治疗阿尔茨海默病的机制

人参皂苷Rg1具有抗氧化、抗衰老、抑制细胞凋亡、改善认知功能的作用。有研究表明，脑源性神经营养因子与学习记忆能力密切相关，在阿尔茨海默病神经元的修复及结构重建中起着重要作用。一项关于“Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer’s disease”的研究显示，人参皂苷Rg1可以上调阿尔茨海默病大鼠脑片模型中脑源性神经营养因子的表达，抑制tau蛋白发生磷酸化。作者推测，人参皂苷Rg1可以降低大鼠脑片阿尔茨海默病模型P-tau的蛋白表达水平，从而可以减缓神经纤维缠结的形成；还可以上调与学习记忆密切相关蛋白脑源性神经营养因子的表达，从而改善学习记忆能力，以此发挥抗痴呆作用。相关研究成果发表在《中国神经再生研究（英文版）》杂志于2012年12月36期出版的杂志上。

doi:10.3969/j.issn.1673-5374.2012.36.002
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Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer’s disease**

Xi Li1, Ming Li1, Yuan Li2, Qiankun Quan3, Juan Wang4

Ginsenoside Rg1 inhibits oxidation, aging and cell apoptosis, and improves cognitive function. In this study, we pretreated rat brain tissue sections with ginsenoside Rg1, and established brain slice models of Alzheimer’s disease induced by okadaic acid. The results revealed that ginsenoside Rg1 pretreatment suppressed the increase in phosphorylated Tau protein expression induced by incubation with okadaic acid, and reduced brain-derived neurotrophic factor expression. These results suggest that ginsenoside Rg1 upregulates brain-derived neurotrophic factor expression and inhibits Tau protein phosphorylation in brain slices from a rat model of Alzheimer’s disease.