Diabetologia：人骨骼肌中的线粒体H + -ATP合成酶及其对血脂异常和胰岛素抵抗的作用

2017-10-27 MedSci MedSci原创

线粒体是2型糖尿病代谢表型的重要调节因子。线粒体生理学的一个关键因素是H + -ATP合成酶。其生理抑制因子、ATP酶抑制因子1（IF1）的表达和活性可控制组织稳态、代谢重新编程和信号传导。近日，国际杂志《Diabetologia》上在线发表一项关于人骨骼肌中的线粒体H + -ATP合成酶及其对血脂异常和胰岛素抵抗的作用的研究。本研究目的是描述IF1在调节肥胖和糖尿病骨骼肌代谢中的作用。

线粒体是2型糖尿病代谢表型的重要调节因子。线粒体生理学的一个关键因素是H + -ATP合成酶。其生理抑制因子、ATP酶抑制因子1（IF1）的表达和活性可控制组织稳态、代谢重新编程和信号传导。近日，国际杂志《Diabetologia》上在线发表一项关于人骨骼肌中的线粒体H + -ATP合成酶及其对血脂异常和胰岛素抵抗的作用的研究。本研究目的是描述IF1在调节肥胖和糖尿病骨骼肌代谢中的作用。研究人员检查了肥胖和2型糖尿病队列中100个人体骨骼肌活检样本的新陈代谢的特点。并描述了H + -ATP合成酶，IF1和关键线粒体蛋白的表达和活性，包括与BMI，空腹血浆胰岛素，空腹血浆葡萄糖和HOMA-IR的关系。同时，IF1在来自相同活组织检查的人肌管的主要培养物中也被过表达，以揭示在骨骼肌中H + -ATP合成酶的病理抑制可能发挥的作用。结果表明，2型糖尿病和肥胖症通过不同的机制以损害人类骨骼肌中的H + -ATP合成酶活性（其催化亚单位减少76％，IF1表达增加280％），并揭示了一个新的IF1影响脂质代谢的途径。在机理上，IF1改变肥胖（84％对照）和糖尿病（76％对照）患者肌管的α-

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2018-08-07 仁心济世

#DIA#

24 0
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2018-06-11 baoya

#胰岛#

31 0
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2017-12-23 ms5439512287675881

#BET#

26 0
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2017-10-29 bugit

#血脂异常#

21 0
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2017-10-29 ms1065684921169360

#骨骼肌#

29 0
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2017-10-29 listen320

#ATP#

33 0
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2017-10-28 Drhzm308

谢谢.学习了

45 0
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2017-10-27 中医痴

不错的.学习了.谢谢分享!

54 0

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