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CLIN CANCER RES：头颈部鳞状细胞癌患者分子改变情况及Buparlisib疗效

2018-06-10 MedSci MedSci原创

头颈部鳞状细胞癌分子改变buparlisib
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BERIL-1是一项多中心的Ⅱ期临床试验，CLIN CANCER RES近期发表了一篇文章，对BERIL-1试验进行分析以寻找Buparlisib联合紫杉醇治疗反应的分子标志。

BERIL-1是一项多中心的Ⅱ期临床试验，CLIN CANCER RES近期发表了一篇文章，对BERIL-1试验进行分析以寻找Buparlisib联合紫杉醇治疗反应的分子标志。

接受过铂类化疗后出现疾病进展的复发或转移头颈部鳞状细胞癌患者接受Buparlisib联合紫杉醇或安慰剂联合紫杉醇治疗。使用二代测序或免疫组化分析肿瘤组织和ctDNA分子变化及免疫改变。158例患者的分子数据可用。研究结果表明，最常见的突变基因为TP53，FAT1，TET2，KMT2D，PIK3CA，NOTCH1，NFE2L2，NOTCH，CCND和CDKN2A。HPV阴性，TP53突变或低突变负荷的头颈部鳞状细胞癌患者接受Buparlisib联合紫杉醇治疗有总生存获益。瘤内TILs≥10%，基质TILs≥15%，瘤内CD8+细胞≥5%，基质CD8+细胞≥10%或浸润切缘CD8+细胞＞25%的患者接受联合治疗也会有总生存获益。在这些患者中也观察到Buparlisib联合紫杉醇治疗的无进展生存获益。

文章最后认为，TP53突变，HPV阴性，低突变负荷或高TILs或CD8+细胞浸润增加Buparlisib联合紫杉醇治疗的生存获益。

原始出处：
Denis Soulieres,Lisa Licitra,et al.Molecular Alterations and Buparlisib Efficacy in Patients with Squamous Cell Carcinoma of the Head and Neck:Biomarker Analysis from BERIL-1.CLIN CANCER RES.June 2018 doi：10.1158/1078-0432.CCR-17-2644

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    2019-03-18 qingting

    #细胞癌#

    0

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    2019-03-08 liuyong2989

    #buparlisib#

    0

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    2018-06-16 chenhongpeng

    #uPAR#

    0

  4. 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content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jun 10 10:56:26 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-12 Smile2680

    #头颈部鳞状细胞癌#

    0

  5. 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content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jun 10 10:56:26 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-12 wshxjq

    #头颈部#

    0

  6. 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content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jun 10 10:56:26 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-12 木头人519

    #颈部#

    0

  7. 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encodeId=3c4e32323415, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Jun 11 07:16:14 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031802, encodeId=d33b103180239, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Jun 10 12:36:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323048, encodeId=0e17323048de, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jun 10 10:56:26 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-11 清风拂面

    谢谢分享学习

    0

  8. 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encodeId=3c4e32323415, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Jun 11 07:16:14 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031802, encodeId=d33b103180239, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Jun 10 12:36:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323048, encodeId=0e17323048de, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jun 10 10:56:26 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-11 kafei

    学习学习谢谢

    0

  9. 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encodeId=3c4e32323415, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Jun 11 07:16:14 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031802, encodeId=d33b103180239, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Jun 10 12:36:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323048, encodeId=0e17323048de, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jun 10 10:56:26 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 内科新手

    谢谢梅斯提供这么好的信息，学到很多

    0

  10. 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encodeId=3c4e32323415, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Jun 11 07:16:14 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031802, encodeId=d33b103180239, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Jun 10 12:36:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323048, encodeId=0e17323048de, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jun 10 10:56:26 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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头颈部鳞状细胞癌（HNSCC）由不同亚群细胞组成，异质性较大。CD271与肿瘤源发细胞亚群有关。CLIN CANCER RES近期发表了一篇文章，研究CD271在调节HNSCC转移性特征方面的作用

BJC：SKLB188抑制头颈部鳞状细胞癌生长

约90%的头颈部鳞状细胞癌存在EGFR过表达，与不良预后有关。因此，靶向EGFR是头颈部细胞鳞状细胞癌的理想治疗方式。目前已有进行临床试验的几种EGFR抑制剂，但是这些抑制剂的效果均未优于显着化疗药物。发展一种理想的EGFR抑制剂治疗头颈部鳞状细胞癌迫在眉睫。BJC近期发表了一篇文章，研究一种新的EGFR抑制剂治疗头颈部鳞状细胞癌的实验结果。

CLIN CANCER RES：厚朴酚通过下调存活素增加头颈部鳞状细胞癌放疗敏感性

之前的研究表明存活素在头颈部鳞状细胞癌中多种作用。CLIN CANCER RES近期发表了一篇文章，研究头颈部鳞状细胞癌中存活素表达的临床意义，头颈部鳞状细胞癌细胞进行放疗后存活素在DNA损伤修复中的功能以及厚朴酚通过下调存活素增强放疗效果的能力。

Ann Oncol：顺铂+西妥昔单抗+再放疗对于复发性或第二原发性头颈部鳞状细胞癌患者可行

头颈部鳞状细胞癌患者外照射治疗后，常会发生局部区域复发，造成死亡。对于复发性或第二原发性头颈部鳞状细胞癌患者，哪种治疗方案有效性强，且安全性高？美国克里夫兰大学医院凯斯西储大学放射肿瘤系Min Yao博士给出了一个可行的方案。1月15日，《Annals of Oncology》对其研究结果进行了报道。

CLIN CANCER RES：NOTCH4-HEY1通路诱导头颈部鳞状细胞癌上皮间质化

近期一些研究发现约20%的头颈部鳞状细胞癌（HNSCC）存在NOTCH1和NOTCH3突变。与其他类型肿瘤相似，这些研究发现NOTCH通路与HNSCC进展密切相关。但是，NOTCH4在HNSCC中的作用尚不清楚。CLIN CANCER RES近期发表了一篇文章研究这一问题。

Int J Cancer：连土豆、大米都不能吃了？碳水化合物摄入量与头颈部癌症疾病有关

目前尚没有研究评估碳水化合物摄入量与头颈部鳞状细胞癌（HNSCC）预后之间的关系。本文前瞻性的研究了414例新诊断HNSCC患者的治疗前和治疗后碳水化合物摄入量和复发率，全因死亡率和HNSCC特异性死亡率之间的关系。数据表明治疗前高碳水化合物摄入量可能与头颈部鳞癌患者的不良预后相关，但还需要临床干预试验来进一步验证这一假设。