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J Genomics：sncRNAs或可用于肾上腺皮质癌的诊断及预后

2017-09-29 MedSci MedSci原创

肾上腺皮质癌sncRNAs
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肾上腺皮质癌（ACC）是一种相对罕见但侵袭性强的癌症，儿童和成人均可发生。非编码小RNAs（sncRNAs）在ACC的发生中发挥了重要的作用，且或可作为该疾病诊断预后和治疗的生物标记物。本研究中，研究人员试图确定与肾上腺恶性肿瘤相关的sncRNAs。研究人员得到了来自45 名例ACC和30例肾上腺皮质腺瘤（ACA）的样本小RNA测序的数据，并比较其sncrna表达谱的差异。结果，首先，研究人员重新

肾上腺皮质癌（ACC）是一种相对罕见但侵袭性强的癌症，儿童和成人均可发生。非编码小RNAs（sncRNAs）在ACC的发生中发挥了重要的作用，且或可作为该疾病诊断预后和治疗的生物标记物。

本研究中，研究人员试图确定与肾上腺恶性肿瘤相关的sncRNAs。研究人员得到了来自45 名例ACC和30例肾上腺皮质腺瘤（ACA）的样本小RNA测序的数据，并比较其sncrna表达谱的差异。

结果，首先，研究人员重新将小RNA 测序与miRBase 21版本进行匹配检查，发现与ACA样本相比，ACC样本的147个miRNA表达异常（P＜0.05）。差异表达miRNAs的通路分析发现，p53信号通路对ACC样本的影响非常明显。对于其他类型的小分子RNA进一步检查坚定了 ACC样本中16 piRNAs、48 lncRNAs 和19 sn/snoRNAs。

总之，该研究结果表明，公开可用的资源有利于发现新的生物标志物，并可改善患者的住院治疗；但是仍需进行进一步的研究以探究基因表达与肿瘤分级的关系。

原始出处：

Srinivas V. Koduru, Ashley N. Leberfinger, Dino J. Ravnic. Small Non-coding RNA Abundance in Adrenocortical Carcinoma: A Footprint of a Rare Cancer. J Genomics. 2017; 5: 99–118. Published online 2017 Sep 8. doi: 10.7150/jgen.22060.


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    2018-09-10 yanjie6253_56072842

    #CRN#

    0

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    2018-09-11 liuquan

    #肾上腺皮质癌#

    0

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    2018-05-26 luckyshitiancai_42705684

    #genomics#

    0

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    2018-02-24 xuyong523

    #肾上腺#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2005649, encodeId=91db2005649b7, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Mon Sep 10 11:11:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670338, encodeId=354516e03381a, content=<a href='/topic/show?id=81c08243e51' target=_blank style='color:#2F92EE;'>#肾上腺皮质癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82437, encryptionId=81c08243e51, topicName=肾上腺皮质癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d27026610809, createdName=liuquan, createdTime=Tue Sep 11 03:11:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077802, encodeId=cea820e7802e7, content=<a href='/topic/show?id=6f8ee950ba' target=_blank style='color:#2F92EE;'>#genomics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7950, encryptionId=6f8ee950ba, topicName=genomics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, createdName=luckyshitiancai_42705684, createdTime=Sat May 26 22:11:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895097, encodeId=3ce5189509e68, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Sat Feb 24 08:11:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005434, encodeId=b1a3200543498, content=<a href='/topic/show?id=d09f155461e' target=_blank style='color:#2F92EE;'>#RNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15546, encryptionId=d09f155461e, topicName=RNAs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Sun Sep 09 19:11:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249399, encodeId=7fa7249399cd, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Oct 01 11:29:54 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248900, encodeId=fc172489009d, content=好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Sep 29 22:12:30 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248883, encodeId=b3ec24888394, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Sep 29 21:16:53 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248849, encodeId=6a3c24884931, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Sep 29 19:56:35 CST 2017, time=2017-09-29, status=1, ipAttribution=)]
    2018-09-09 dzx0922889

    #RNAs#

    0

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    2017-10-01 大爰

    学习并分享!!

    0

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    2017-09-29 ylzr123

    好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!

    0

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    2017-09-29 天涯183

    非常好的文章.学习了

    0

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    2017-09-29 changjiu

    学习了.谢谢

    0