Chest:ICU患者血小板输注情况分析

2016-10-02 xing.T MedSci原创

该研究结果表明当血小板计数≥50×109/L时,血小板输注在ICU是很常用的方法,一次血小板输注可增加血小板计数23×109/L,有20%左右的血小板输注是无效的,ABO血型不合被确定为一个可改变的危险因素。这些数据可以帮助减少血小板的过度使用,并提高输血质量。

血小板输注常用于危重病人的治疗,但输注血小板的阈值、递增计数和无效输血的预测仍不清楚。近日,在Chest杂志上发表了一篇旨在解决这些问题的研究文章。

在这项回顾性研究中纳入了从2006年到2015年在三家加拿大学术医院连续住院的成年非肿瘤患者,并在ICU里进行了血小板输注。研究者从验证的输血数据库中收集数据,确定血小板输注无效的独立预测因子,即通过血小板输注,血小板计数增加<5×109/L,在研究中尽管血小板计数正常,研究对象也能够接受血小板输注。

研究者确定了7073例重症监护患者,在此期间,共输注血小板15879份。大多数血小板输注(78.7%)用于心脏手术。基于对5700份输血的分析,平均输血前血小板计数为87×1×109/L(四分位距[IQR]57-130),输血前血小板计数≥50×109/L≥150×109/L分别占79.6%17.8%

尽管血小板计数正常,但其输注血小板的原因包括活动性出血、接受抗血小板或抗凝治疗的手术患者,研究者发现患者平均血小板计数增加为23×109/LIQR7-44),并且21.8%的血小板输注是无效的。ABO血型不合、脓毒症、肝脏疾病和冻干血浆输注都与血小板计数较少相关。

该研究结果表明:当血小板计数≥50×109/L时,血小板输注在ICU是很常用的方法,一次血小板输注可增加血小板计数23×109/L,有20%左右的血小板输注是无效的,ABO血型不合被确定为一个可改变的危险因素。这些数据可以帮助减少血小板的过度使用,并提高输血质量。

原始出处:

Shuoyan Ning. et al. Platelet Transfusion Practices in the ICU:Data From a Large Transfusion Registry. Chest. 2016.

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    2016-10-12 Smile2680
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