Diabetic Med:2型糖尿病抑郁综合征的临床危险因素?

2018-10-25 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于2型糖尿病抑郁综合征的临床危险因素的弗里曼特尔糖尿病的研究,以确定2型糖尿病患者抑郁综合征的早期临床预测因子。 本研究在基线评估15年后,对325名2型糖尿病患者进行了抑郁综合征评估,其中包括使用生活质量量表获得的抗抑郁药物使用和抑郁症状的信息。使用9项患者健康问卷和短暂终身抑郁量表评估随访时和终身抑郁综合征,并考虑抗抑郁药的使

近日,国际杂志 《Diabetic Med》上在线发表一项关于2糖尿病抑郁综合征的临床危险因素的弗里曼特尔糖尿病的研究,以确定2糖尿病患者抑郁综合征的早期临床预测因子。

本研究在基线评估15年后,对3252型糖尿病患者进行了抑郁综合征评估,其中包括使用生活质量量表获得的抗抑郁药物使用和抑郁症状的信息。使用9项患者健康问卷和短暂终身抑郁量表评估随访时和终身抑郁综合征,并考虑抗抑郁药的使用。在未满足患者健康问卷标准的情况下,对抗抑郁药物的使用进行了包容性和排他性的分析。

研究显示基线水平:参与者年龄为57.2±9.3岁,中位数(四分位距)糖尿病病程为2.20.6-6.0)年。平均随访14.7±1.1年后,81名参与者(24.9%)患有抑郁综合征(14.8%由患者健康问卷定义,10.2%由抗抑郁药定义),31.4%报告终生抑郁症,占10.2%参与者糖尿病发病。随着逻辑回归(包括抗抑郁药),后续随访时抑郁综合征与教育水平[优势比0.3995CI 0.20-0.75]和抗抑郁药[比值比0.1195CI 0.03-0.36]呈负相关,与糖尿病发病前的抑郁史呈正相关[比值比2.7995CI 1.24-6.27]。在特定的抗抑郁药的模型中,抑郁综合症与基线抑郁症状[优势比2.5795%CI 1.32-5.03]和抗抑郁药的使用[优势比3.5495% cl 1.20-10.42]为正相关,与教育水平[优势比0.3995%cl 0.19-0.81]成负相关。

研究表明,可在2型糖尿病发病后早期发现抑郁症的危险因素。早期抑郁症状或其治疗和/或抑郁史的存在可能是脆弱性的指标。对于2型糖尿病患者,晚期抑郁综合征的早期危险分层是可行的,并且可以帮助抑郁症治疗或预防

原始出处:

D. G. Bruce, W. A. Davis, S. E. Starksteinet al. Clinical risk factors for depressive syndrome in Type 2 diabetes: the Fremantle Diabetes Study

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    2018-11-04 wxl882001

    了解一下

    0

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    2018-10-25 misszhang

    谢谢MedSci提供最新的资讯

    0

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