Aliment Pharmacol Ther:全球性社会卫生问题——幽门螺杆菌复发亟待解决

2017-11-15 王淳 环球医学资讯

2017年11月,发表在《Aliment Pharmacol Ther》的一项由中国和美国科学家进行的系统评价和meta分析,考察了幽门螺杆菌的全球复发率及其与与社会经济和卫生条件的相关性。

2017年11月,发表在《Aliment Pharmacol Ther》的一项由中国和美国科学家进行的系统评价和meta分析,考察了幽门螺杆菌的全球复发率及其与与社会经济和卫生条件的相关性。

背景:根除治疗后幽门螺杆菌复发率的最新信息缺乏。

目的:旨在评估幽门螺杆菌根除治疗后的全球复发率,证实其与社会经济和卫生条件的相关性。

方法:对Pubmed、Embase和Cochrane图书馆进行了系统检索,旨在鉴别潜在相关的发表文献,使用了以下关键词:幽门螺杆菌及简写、复发、复燃、再感染

结果:总共分析了132项研究(53934患者-年)。每项研究都根据患者年进行了加权。幽门螺杆菌的全球年复发率、再感染率和复燃率分别为4.3%(95%置信区间[ CI],4~5)、3.1%((95% CI ,2~5)、2.2%((95% CI ,1~3)。幽门螺杆菌复发率与人类发展指数(HDI)负相关(即,非常高HDI为3.1%(95% CI ,2~4)、高和中HDI为6.2%(95% CI ,4~8)、低HDI为10.9%(95% CI ,6~18))(P<0.01),与幽门螺杆菌患病率直接相关(局部幽门螺杆菌患病率非常高、高、中、低的国家分别为10.9%(95% CI ,7~16)、3.7%(95% CI ,3~5)、3.4%(95% CI ,2~5)、1.6%(95% CI ,0.5~3)(P<0.01)。1990、2000和2010年代,全球复发率仍然相对稳定,但是不同地区具有差异(P<0.05)。

结论:幽门螺杆菌复发仍然是与社会经济和卫生条件密切相关的问题。需要一种方法降低发展中国家复发率。

原始出处:

Hu Y,et al.,Systematic review with meta-analysis: the global recurrence rate of Helicobacter pylori.Aliment Pharmacol Ther. 2017 Nov;46(9):773-779.

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    2018-03-31 jj000001
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    2018-09-25 hb2008ye
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    2017-11-16 186****0580(小山羊)

    学习了谢谢了

    0

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幽门螺杆菌导致的胃外疾病

幽门螺旋杆菌(HP)是一种螺旋形、微需氧、对生长条件要求十分苛刻的革兰氏阴性杆菌。1983年首次从慢性活动性胃炎患者的胃粘膜活检组织中分离成功,是目前所知能够在人胃中生存的惟一微生物种类。幽门螺旋杆菌感染可引起慢性胃炎,消化性溃疡,胃癌,胃黏膜相关淋巴组织恶性淋巴瘤等胃内疾病。但幽门螺杆菌导致的胃外疾病,你知道吗?