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Am J Clin Nutr：鱼和蛋摄入多 幽门螺杆菌根除成功率低

2017-08-22 徐晓涵 环球医学

鱼蛋摄入幽门螺杆菌根除成功率
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2017年8月，发表在《Am J Clin Nutr》的一项由日本科学家进行的研究，发现了日本人较高的膳食胆固醇和ω-3脂肪酸摄入与较低的幽门螺杆菌治疗成功率相关。

2017年8月，发表在《Am J Clin Nutr》的一项由日本科学家进行的研究，发现了日本人较高的膳食胆固醇和ω-3脂肪酸摄入与较低的幽门螺杆菌治疗成功率相关。

背景：幽门螺杆菌感染是十二指肠溃疡、胃炎和胃癌已知的危险因素。根除幽门螺杆菌能成功治疗这些疾病，然而，目前根除成功率在下降。与营养摄入之间的相互作用可能会造成这种下降。

目的：旨在考察食物和营养摄入对幽门螺杆菌根除治疗的影响。

设计：本项研究中，4104名经行内镜检查的患者检测了血清幽门螺杆菌抗体（2046例阳性，51.0%），并且使用食物频率问卷（FFQ）评估了他们的食物摄入情况。阳性个体中，内镜检查表明，389人（19.0%）患有胃炎和/或十二指肠溃疡，并且13C-尿素呼气试验（UBT）也为阳性。这389人接受了1周的兰索拉唑、阿莫西林和克拉霉素的幽门螺杆菌根除治疗，治疗后8周，进行了二次UBT。352名患者具有完整的人口统计学特征、血脂、胰岛素、糖化血红蛋白、C反应蛋白（CRP）、肌酐浓度以及完全FFQ。多变量logistic回归分析用于确定与成功幽门螺杆菌根除治疗相关的因素。

结果：根除治疗的成功率为60.4%（235/389）。与根除治疗失败相关的因素包括年龄增加（P=0.02）、较高的CRP浓度（P＜0.01）、较高的膳食胆固醇（P＜0.01）或鸡蛋摄入（P＜0.01）、较高的ω-3脂肪酸（P=0.02）或鱼摄入（P=0.01）、较高的维生素D摄入（P=0.02）。此外，较高的鱼摄入与较高的维生素D摄入相关性极大。研究局限性为未评估幽门螺杆菌的抗菌药物耐药情况。

结论：结果表明，对幽门螺杆菌阳性的胃炎和/或十二指肠溃疡的患者，较高的鸡蛋和鱼肉摄入量会对成功根除幽门螺杆菌造成阻碍。

原始出处：
Ikezaki H, Furusyo N, Jacques PF, et al.Higher dietary cholesterol and ω-3 fatty acid intakes are associated with a lower success rate of Helicobacter pylori eradication therapy in Japan.Am J Clin Nutr. 2017 Aug;106(2):581-588. doi: 10.3945/ajcn.116.144873. Epub 2017 Jun 28.

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    2018-03-08 kcb069

    #螺杆菌#

    0

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    2017-12-15 风铃830

    #根除#

    0

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    2017-08-28 虈亣靌

    内容丰富.值得学习

    0

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    2017-08-23 184****9840

    学习了受益匪浅

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1811731, encodeId=24bb1811e3134, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Thu Mar 08 15:03:00 CST 2018, time=2018-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683648, encodeId=ddab16836481d, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Fri Dec 15 15:03:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238061, encodeId=875e2380614e, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Aug 28 18:27:47 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236208, encodeId=41022362083e, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Aug 23 06:48:07 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236077, encodeId=1f1b2360e78f, content=很好学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27762113155, createdName=小铭的皮普, createdTime=Tue Aug 22 17:49:41 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236055, encodeId=c76123605537, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Tue Aug 22 17:00:23 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-22 小铭的皮普

    很好学习了谢谢分享

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    2017-08-22 中医痴

    不错的.学习了.谢谢分享!

    0