J Rheumatol:类风湿性关节炎的心血管事件风险

2019-11-21 xiangting MedSci原创

类风湿性关节炎(RA)的心血管(CV)疾病(CVD)风险升高。但是,探讨这种风险的长期随访研究很少。   CARRÉ研究(心血管研究和类风湿性关节炎)是一项前瞻性队列研究,旨在调查353例长期RA患者的CVD及其危险因素。在​​基线以及研究开始后的3年、10年和15年对CV终点进行评估,并与对照队列(n=2540)进行比较,其中包括大量的2型糖尿病(DM)患者。 &nb

类风湿性关节炎(RA)的心血管(CV)疾病(CVD)风险升高。但是,探讨这种风险的长期随访研究很少。

CARRÉ研究(心血管研究和类风湿性关节炎)是一项前瞻性队列研究,旨在调查353例长期RA患者的CVD及其危险因素。在​​基线以及研究开始后的3年、10年和15年对CV终点进行评估,并与对照队列(n=2540)进行比较,其中包括大量的2型糖尿病(DM)患者。

2973人年内95RA患者出现CV事件,使得每100人年的发病率为3.20。对照队列在18874人年期间报告了257CV事件,使得每100人年的发病率为1.36。与非糖尿病患者相比,RAHR 2.0795CI 1.57–2.72p<0.01)和DMHR 1.5195CI 1.02–2.22p=0.04)的年龄和性别校正CV事件HR升高。在对心血管危险因素进行进一步调整后,RAHR仍升高(HR 1.8295CI 1.32–2.50p<0.01)。同时患RADM或胰岛素抵抗患者发生CVDHR最高(分别为2.2195CI 1.01-4.80p = 0.0462.6795CI 1.30-5.46p<0.01)。

RA患者CV事件的发病率是普通人群的两倍以上。RA患者比DM患者具有更高的CVD风险。在对传统的心血管风险因素进行调整后,这种风险仍然存在,这表明全身性炎症是心血管风险的独立因素。

原始出处:

Rabia Agca. Cardiovascular Event Risk in Rheumatoid Arthritis Compared with Type 2 Diabetes: A 15-year Longitudinal Study. J Rheumatol. 15 November 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

 

 



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    2019-11-23 lmm397
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    2019-11-21 1274026em12暂无昵称

    类风湿性关节炎

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